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New page: left|200px<br /><applet load="1znk" size="450" color="white" frame="true" align="right" spinBox="true" caption="1znk, resolution 1.6Å" /> '''Strong Solute-Solute ...
 
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[[Image:1znk.gif|left|200px]]<br /><applet load="1znk" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1znk, resolution 1.6&Aring;" />
'''Strong Solute-Solute Dispersive Interactions in a Protein-Ligand Complex'''<br />


==Overview==
==Strong Solute-Solute Dispersive Interactions in a Protein-Ligand Complex==
The contributions of solute-solute dispersion interactions to binding, thermodynamics have generally been thought to be small, due to the, surmised equality between solute-solvent dispersion interactions prior to, the interaction versus solute-solute dispersion interactions following the, interaction. The thermodynamics of binding of primary alcohols to the, major urinary protein (MUP-I) indicate that this general assumption is not, justified. The enthalpy of binding becomes more favorable with increasing, chain length, whereas the entropy of binding becomes less favorable, both, parameters showing a linear dependence. Despite the hydrophobicity of the, interacting species, these data show that binding is not dominated by the, classical hydrophobic effect, but can be attributed to favorable, ligand-protein dispersion interactions.
<StructureSection load='1znk' size='340' side='right'caption='[[1znk]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1znk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZNK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZNK FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=F09:NONAN-1-OL'>F09</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1znk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1znk OCA], [https://pdbe.org/1znk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1znk RCSB], [https://www.ebi.ac.uk/pdbsum/1znk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1znk ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MUP2_MOUSE MUP2_MOUSE] Binds pheromones that are released from drying urine of males. These pheromones affect the sexual behavior of females.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zn/1znk_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1znk ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The contributions of solute-solute dispersion interactions to binding thermodynamics have generally been thought to be small, due to the surmised equality between solute-solvent dispersion interactions prior to the interaction versus solute-solute dispersion interactions following the interaction. The thermodynamics of binding of primary alcohols to the major urinary protein (MUP-I) indicate that this general assumption is not justified. The enthalpy of binding becomes more favorable with increasing chain length, whereas the entropy of binding becomes less favorable, both parameters showing a linear dependence. Despite the hydrophobicity of the interacting species, these data show that binding is not dominated by the classical hydrophobic effect, but can be attributed to favorable ligand-protein dispersion interactions.


==About this Structure==
Strong solute-solute dispersive interactions in a protein-ligand complex.,Malham R, Johnstone S, Bingham RJ, Barratt E, Phillips SE, Laughton CA, Homans SW J Am Chem Soc. 2005 Dec 7;127(48):17061-7. PMID:16316253<ref>PMID:16316253</ref>
1ZNK is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with CD and F09 as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1ZNK OCA].


==Reference==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
Strong solute-solute dispersive interactions in a protein-ligand complex., Malham R, Johnstone S, Bingham RJ, Barratt E, Phillips SE, Laughton CA, Homans SW, J Am Chem Soc. 2005 Dec 7;127(48):17061-7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16316253 16316253]
</div>
<div class="pdbe-citations 1znk" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Single protein]]
[[Category: Barratt E]]
[[Category: Barratt, E.]]
[[Category: Bingham RJ]]
[[Category: Bingham, R.J.]]
[[Category: Homans SW]]
[[Category: Homans, S.W.]]
[[Category: Johnstone S]]
[[Category: Johnstone, S.]]
[[Category: Laughton CA]]
[[Category: Laughton, C.A.]]
[[Category: Malham R]]
[[Category: Malham, R.]]
[[Category: Phillips SE]]
[[Category: Phillips, S.E.]]
[[Category: CD]]
[[Category: F09]]
[[Category: beta-barrel]]
[[Category: lipocalin]]
 
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