2pv0: Difference between revisions

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{{Seed}}
[[Image:2pv0.png|left|200px]]


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==DNA methyltransferase 3 like protein (DNMT3L)==
The line below this paragraph, containing "STRUCTURE_2pv0", creates the "Structure Box" on the page.
<StructureSection load='2pv0' size='340' side='right'caption='[[2pv0]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2pv0]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PV0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PV0 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
{{STRUCTURE_2pv0|  PDB=2pv0  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pv0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pv0 OCA], [https://pdbe.org/2pv0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pv0 RCSB], [https://www.ebi.ac.uk/pdbsum/2pv0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pv0 ProSAT]</span></td></tr>
 
</table>
===DNA methyltransferase 3 like protein (DNMT3L)===
== Function ==
 
[https://www.uniprot.org/uniprot/DNM3L_HUMAN DNM3L_HUMAN] Catalytically inactive regulatory factor of DNA methyltransferases. It is essential for the function of DNMT3A and DNMT3B. Activates DNMT3A and DNMT3B by binding to their catalytic domain. Accelerates the binding of DNA and AdoMet to the methyltransferases and dissociates from the complex after DNA binding to the methyltransferases. Recognizes unmethylated histone H3 lysine 4 (H3K4) and induces de novo DNA methylation by recruitment or activation of DNMT3.<ref>PMID:17687327</ref>  
 
== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
The line below this paragraph, {{ABSTRACT_PUBMED_17687327}}, adds the Publication Abstract to the page
Check<jmol>
(as it appears on PubMed at http://www.pubmed.gov), where 17687327 is the PubMed ID number.
  <jmolCheckbox>
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    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pv/2pv0_consurf.spt"</scriptWhenChecked>
{{ABSTRACT_PUBMED_17687327}}
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 
    <text>to colour the structure by Evolutionary Conservation</text>
==About this Structure==
  </jmolCheckbox>
2PV0 is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PV0 OCA].  
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2pv0 ConSurf].
 
<div style="clear:both"></div>
==Reference==
== References ==
<ref group="xtra">PMID:17687327</ref><references group="xtra"/>
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Cheng, X.]]
[[Category: Large Structures]]
[[Category: De novo dna methylation]]
[[Category: Cheng X]]
[[Category: Dnmt3l]]
[[Category: Transferase regulator]]
[[Category: Unmethylated h3k4]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 22:05:15 2009''
Retrieved from "https://proteopedia.org/2pv0"