1osv: Difference between revisions

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{{Seed}}
[[Image:1osv.png|left|200px]]


<!--
==STRUCTURAL BASIS FOR BILE ACID BINDING AND ACTIVATION OF THE NUCLEAR RECEPTOR FXR==
The line below this paragraph, containing "STRUCTURE_1osv", creates the "Structure Box" on the page.
<StructureSection load='1osv' size='340' side='right'caption='[[1osv]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1osv]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OSV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OSV FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CHC:6-ETHYL-CHENODEOXYCHOLIC+ACID'>CHC</scene></td></tr>
{{STRUCTURE_1osv| PDB=1osv |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1osv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1osv OCA], [https://pdbe.org/1osv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1osv RCSB], [https://www.ebi.ac.uk/pdbsum/1osv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1osv ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NR1H4_RAT NR1H4_RAT] Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) and activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 within its gene locus (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/os/1osv_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1osv ConSurf].
<div style="clear:both"></div>


===STRUCTURAL BASIS FOR BILE ACID BINDING AND ACTIVATION OF THE NUCLEAR RECEPTOR FXR===
==See Also==
 
*[[Bile acid receptor 3D structures|Bile acid receptor 3D structures]]
 
__TOC__
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</StructureSection>
The line below this paragraph, {{ABSTRACT_PUBMED_12718893}}, adds the Publication Abstract to the page
[[Category: Large Structures]]
(as it appears on PubMed at http://www.pubmed.gov), where 12718893 is the PubMed ID number.
[[Category: Mus musculus]]
-->
{{ABSTRACT_PUBMED_12718893}}
 
==About this Structure==
1OSV is a 5 chains structure of sequences from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OSV OCA].
 
==Reference==
<ref group="xtra">PMID:12718893</ref><references group="xtra"/>
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
[[Category: Devarakonda, S.]]
[[Category: Devarakonda S]]
[[Category: Han, Q.]]
[[Category: Han Q]]
[[Category: Harp, J M.]]
[[Category: Harp JM]]
[[Category: Khorasanizadeh, S.]]
[[Category: Khorasanizadeh S]]
[[Category: Mi, L Z.]]
[[Category: Mi LZ]]
[[Category: Pellicciari, R.]]
[[Category: Pellicciari R]]
[[Category: Rastinejad, F.]]
[[Category: Rastinejad F]]
[[Category: Willson, T M.]]
[[Category: Willson TM]]
[[Category: Bile acid]]
[[Category: Coactivator]]
[[Category: Lbd]]
[[Category: Nuclear receptor]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 23:27:13 2009''
Retrieved from "https://proteopedia.org/1osv"