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New page: left|200px<br /><applet load="1zxj" size="450" color="white" frame="true" align="right" spinBox="true" caption="1zxj, resolution 2.80Å" /> '''Crystal structure of...
 
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[[Image:1zxj.gif|left|200px]]<br /><applet load="1zxj" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1zxj, resolution 2.80&Aring;" />
'''Crystal structure of the hypthetical Mycoplasma protein, MPN555'''<br />


==Overview==
==Crystal structure of the hypthetical Mycoplasma protein, MPN555==
The crystal structure of the hypothetical protein MPN555 from Mycoplasma, pneumoniae (gi|1673958) has been determined to a resolution of 2.8, Angstrom using anomalous diffraction data at the Se-peak wavelength., Structure determination revealed a mostly alpha-helical protein with a, three-lobed shape. The three lobes or fingers delineate a central binding, groove and additional grooves between lobes 1 and 3 and between lobes 2, and 3. For one of the molecules in the asymmetric unit, the central, binding pocket was filled with a peptide from the uncleaved N-terminal, affinity tag. The MPN555 structure has structural homology to two, bacterial chaperone proteins: SurA and trigger factor from Escherichia, coli. The structural data and the homology to other chaperone proteins, suggests an involvement in protein folding as a molecular chaperone for, MPN555.
<StructureSection load='1zxj' size='340' side='right'caption='[[1zxj]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[1zxj]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycoplasma_pneumoniae Mycoplasma pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZXJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZXJ FirstGlance]. <br>
1ZXJ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mycoplasma_pneumoniae Mycoplasma pneumoniae]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1ZXJ OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zxj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zxj OCA], [https://pdbe.org/1zxj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zxj RCSB], [https://www.ebi.ac.uk/pdbsum/1zxj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zxj ProSAT], [https://www.topsan.org/Proteins/BSGC/1zxj TOPSAN]</span></td></tr>
==Reference==
</table>
Structure of the hypothetical Mycoplasma protein MPN555 suggests a chaperone function., Schulze-Gahmen U, Aono S, Chen S, Yokota H, Kim R, Kim SH, Acta Crystallogr D Biol Crystallogr. 2005 Oct;61(Pt 10):1343-7. Epub 2005, Sep 28. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16204885 16204885]
== Function ==
[https://www.uniprot.org/uniprot/Y555_MYCPN Y555_MYCPN]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zx/1zxj_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1zxj ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mycoplasma pneumoniae]]
[[Category: Mycoplasma pneumoniae]]
[[Category: Single protein]]
[[Category: Aono S]]
[[Category: Aono, S.]]
[[Category: Kim R]]
[[Category: BSGC, Berkeley.Structural.Genomics.Center.]]
[[Category: Kim S-H]]
[[Category: Kim, R.]]
[[Category: Schulze-Gahmen U]]
[[Category: Kim, S.H.]]
[[Category: Shengfeng C]]
[[Category: Schulze-Gahmen, U.]]
[[Category: Yokota H]]
[[Category: Shengfeng, C.]]
[[Category: Yokota, H.]]
[[Category: berkeley structural genomics center]]
[[Category: bsgc]]
[[Category: mostly alpha helical protein]]
[[Category: protein structure initiative]]
[[Category: psi]]
[[Category: structural genomics]]
[[Category: tri-lobal structure]]
 
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