2jx8: Difference between revisions

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{{Seed}}
[[Image:2jx8.png|left|200px]]


<!--
==Solution structure of hPCIF1 WW domain==
The line below this paragraph, containing "STRUCTURE_2jx8", creates the "Structure Box" on the page.
<StructureSection load='2jx8' size='340' side='right'caption='[[2jx8]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2jx8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JX8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JX8 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jx8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jx8 OCA], [https://pdbe.org/2jx8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jx8 RCSB], [https://www.ebi.ac.uk/pdbsum/2jx8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jx8 ProSAT]</span></td></tr>
{{STRUCTURE_2jx8|  PDB=2jx8  |  SCENE=  }}
</table>
 
== Function ==
===Solution structure of hPCIF1 WW domain===
[https://www.uniprot.org/uniprot/CAPAM_HUMAN CAPAM_HUMAN] Cap-specific adenosine methyltransferase that catalyzes formation of N(6),2'-O-dimethyladenosine cap (m6A(m)) by methylating the adenosine at the second transcribed position of capped mRNAs (PubMed:30467178, PubMed:30487554, PubMed:31279658, PubMed:31279659, PubMed:33428944). Recruited to the early elongation complex of RNA polymerase II (RNAPII) via interaction with POLR2A and mediates formation of m6A(m) co-transcriptionally (PubMed:30467178).<ref>PMID:30467178</ref> <ref>PMID:30487554</ref> <ref>PMID:31279658</ref> <ref>PMID:31279659</ref> <ref>PMID:33428944</ref>
 
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
==About this Structure==
Check<jmol>
2JX8 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JX8 OCA].  
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jx/2jx8_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jx8 ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Aizawa, T.]]
[[Category: Large Structures]]
[[Category: Demura, M.]]
[[Category: Aizawa T]]
[[Category: Hirose, Y.]]
[[Category: Demura M]]
[[Category: Iwamoto, Y.]]
[[Category: Hirose Y]]
[[Category: Kawano, K.]]
[[Category: Iwamoto Y]]
[[Category: Kouno, T.]]
[[Category: Kawano K]]
[[Category: Mizuguchi, M.]]
[[Category: Kouno T]]
[[Category: Ohkuma, Y.]]
[[Category: Mizuguchi M]]
[[Category: Alpha-helix]]
[[Category: Ohkuma Y]]
[[Category: Nucleus]]
[[Category: Phosphorylation]]
[[Category: Protein fragment]]
[[Category: Transcription]]
[[Category: Triple-standed beta-sheet]]
[[Category: Ww domain]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 00:38:11 2009''
Retrieved from "https://proteopedia.org/2jx8"