2vr2: Difference between revisions

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{{Seed}}
[[Image:2vr2.png|left|200px]]


<!--
==Human Dihydropyrimidinase==
The line below this paragraph, containing "STRUCTURE_2vr2", creates the "Structure Box" on the page.
<StructureSection load='2vr2' size='340' side='right'caption='[[2vr2]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2vr2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VR2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VR2 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
{{STRUCTURE_2vr2|  PDB=2vr2  |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vr2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vr2 OCA], [https://pdbe.org/2vr2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vr2 RCSB], [https://www.ebi.ac.uk/pdbsum/2vr2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vr2 ProSAT]</span></td></tr>
 
</table>
===HUMAN DIHYDROPYRIMIDINASE===
== Disease ==
 
[https://www.uniprot.org/uniprot/DPYS_HUMAN DPYS_HUMAN] Dihydropyrimidinuria. The disease is caused by variants affecting the gene represented in this entry.
 
== Function ==
==About this Structure==
[https://www.uniprot.org/uniprot/DPYS_HUMAN DPYS_HUMAN] Catalyzes the second step of the reductive pyrimidine degradation, the reversible hydrolytic ring opening of dihydropyrimidines. Can catalyze the ring opening of 5,6-dihydrouracil to N-carbamyl-alanine and of 5,6-dihydrothymine to N-carbamyl-amino isobutyrate.
2VR2 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VR2 OCA].  
== Evolutionary Conservation ==
[[Category: Dihydropyrimidinase]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vr/2vr2_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vr2 ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Andersson, J.]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C H.]]
[[Category: Andersson J]]
[[Category: Berg, S Van Den.]]
[[Category: Arrowsmith CH]]
[[Category: Berglund, H.]]
[[Category: Berglund H]]
[[Category: Busam, R D.]]
[[Category: Busam RD]]
[[Category: Collins, R.]]
[[Category: Collins R]]
[[Category: Consortium, Structural Genomics.]]
[[Category: Dahlgren LG]]
[[Category: Dahlgren, L G.]]
[[Category: Edwards AM]]
[[Category: Edwards, A M.]]
[[Category: Flodin S]]
[[Category: Flodin, S.]]
[[Category: Flores A]]
[[Category: Flores, A.]]
[[Category: Graslund S]]
[[Category: Graslund, S.]]
[[Category: Hammarstrom M]]
[[Category: Hammarstrom, M.]]
[[Category: Herman MD]]
[[Category: Herman, M D.]]
[[Category: Johansson I]]
[[Category: Johansson, I.]]
[[Category: Kallas A]]
[[Category: Kallas, A.]]
[[Category: Karlberg T]]
[[Category: Karlberg, T.]]
[[Category: Kotenyova T]]
[[Category: Kotenyova, T.]]
[[Category: Lehtio L]]
[[Category: Lehtio, L.]]
[[Category: Moche M]]
[[Category: Moche, M.]]
[[Category: Nilsson ME]]
[[Category: Nilsson, M E.]]
[[Category: Nordlund P]]
[[Category: Nordlund, P.]]
[[Category: Nyman T]]
[[Category: Nyman, T.]]
[[Category: Persson C]]
[[Category: Persson, C.]]
[[Category: Sagemark J]]
[[Category: Sagemark, J.]]
[[Category: Svensson L]]
[[Category: Svensson, L.]]
[[Category: Thorsell AG]]
[[Category: Thorsell, A G.]]
[[Category: Tresaugues L]]
[[Category: Tresaugues, L.]]
[[Category: Van Den Berg S]]
[[Category: Weigelt, J.]]
[[Category: Weigelt J]]
[[Category: Welin, M.]]
[[Category: Welin M]]
[[Category: Wikstrom, M.]]
[[Category: Wikstrom M]]
[[Category: Dhp]]
[[Category: Dhpase]]
[[Category: Dihydropyrimidinase]]
[[Category: Dihydropyrimidine amidohydrolase]]
[[Category: Disease mutation]]
[[Category: Dpy]]
[[Category: Hydantoinase]]
[[Category: Hydrolase]]
[[Category: Metal-binding]]
[[Category: Nucleotide metabolism]]
[[Category: Zinc]]
[[Category: Zn-binding]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 00:46:25 2009''

Latest revision as of 15:29, 13 December 2023

Human Dihydropyrimidinase

2vr2, resolution 2.80Å

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