2e3p: Difference between revisions

Latest revision as of 13:48, 13 March 2024

Crystal structure of CERT START domain in complex with C16-cearmide (P1)

Structural highlights

2e3p is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.4Å
Ligands:	16C
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

CERT_HUMAN The disease is caused by variants affecting the gene represented in this entry.

Function

CERT_HUMAN Shelters ceramides and diacylglycerol lipids inside its START domain and mediates the intracellular trafficking of ceramides and diacylglycerol lipids in a non-vesicular manner.^[1] ^[2] ^[3] ^[4]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

↑ Hanada K, Kumagai K, Yasuda S, Miura Y, Kawano M, Fukasawa M, Nishijima M. Molecular machinery for non-vesicular trafficking of ceramide. Nature. 2003 Dec 18;426(6968):803-9. PMID:14685229 doi:https://dx.doi.org/10.1038/nature02188
↑ Fugmann T, Hausser A, Schoffler P, Schmid S, Pfizenmaier K, Olayioye MA. Regulation of secretory transport by protein kinase D-mediated phosphorylation of the ceramide transfer protein. J Cell Biol. 2007 Jul 2;178(1):15-22. Epub 2007 Jun 25. PMID:17591919 doi:https://dx.doi.org/jcb.200612017
↑ Kudo N, Kumagai K, Tomishige N, Yamaji T, Wakatsuki S, Nishijima M, Hanada K, Kato R. Structural basis for specific lipid recognition by CERT responsible for nonvesicular trafficking of ceramide. Proc Natl Acad Sci U S A. 2008 Jan 15;105(2):488-93. Epub 2008 Jan 9. PMID:18184806
↑ Kudo N, Kumagai K, Matsubara R, Kobayashi S, Hanada K, Wakatsuki S, Kato R. Crystal structures of the CERT START domain with inhibitors provide insights into the mechanism of ceramide transfer. J Mol Biol. 2010 Feb 19;396(2):245-51. Epub 2009 Dec 28. PMID:20036255 doi:10.1016/j.jmb.2009.12.029

Proteopedia Page Contributors and Editors (what is this?)

OCA

[1] Hanada K, Kumagai K, Yasuda S, Miura Y, Kawano M, Fukasawa M, Nishijima M. Molecular machinery for non-vesicular trafficking of ceramide. Nature. 2003 Dec 18;426(6968):803-9. PMID:14685229 doi:https://dx.doi.org/10.1038/nature02188

[2] Fugmann T, Hausser A, Schoffler P, Schmid S, Pfizenmaier K, Olayioye MA. Regulation of secretory transport by protein kinase D-mediated phosphorylation of the ceramide transfer protein. J Cell Biol. 2007 Jul 2;178(1):15-22. Epub 2007 Jun 25. PMID:17591919 doi:https://dx.doi.org/jcb.200612017

[3] Kudo N, Kumagai K, Tomishige N, Yamaji T, Wakatsuki S, Nishijima M, Hanada K, Kato R. Structural basis for specific lipid recognition by CERT responsible for nonvesicular trafficking of ceramide. Proc Natl Acad Sci U S A. 2008 Jan 15;105(2):488-93. Epub 2008 Jan 9. PMID:18184806

[4] Kudo N, Kumagai K, Matsubara R, Kobayashi S, Hanada K, Wakatsuki S, Kato R. Crystal structures of the CERT START domain with inhibitors provide insights into the mechanism of ceramide transfer. J Mol Biol. 2010 Feb 19;396(2):245-51. Epub 2009 Dec 28. PMID:20036255 doi:10.1016/j.jmb.2009.12.029

[1]

[2]

[3]

[4]

@@ Line 1: / Line 1: @@
-{{Seed}}
-[[Image:2e3p.png|left|200px]]
-<!--
+==Crystal structure of CERT START domain in complex with C16-cearmide (P1)==
-The line below this paragraph, containing "STRUCTURE_2e3p", creates the "Structure Box" on the page.
+<StructureSection load='2e3p' size='340' side='right'caption='[[2e3p]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2e3p]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E3P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E3P FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=16C:N-((E,2S,3R)-1,3-DIHYDROXYOCTADEC-4-EN-2-YL)PALMITAMIDE'>16C</scene></td></tr>
-{{STRUCTURE_2e3p|  PDB=2e3p  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e3p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e3p OCA], [https://pdbe.org/2e3p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e3p RCSB], [https://www.ebi.ac.uk/pdbsum/2e3p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e3p ProSAT]</span></td></tr>
+</table>
-===Crystal structure of CERT START domain in complex with C16-cearmide (P1)===
+== Disease ==
+[https://www.uniprot.org/uniprot/CERT_HUMAN CERT_HUMAN] The disease is caused by variants affecting the gene represented in this entry.
+== Function ==
-<!--
+[https://www.uniprot.org/uniprot/CERT_HUMAN CERT_HUMAN] Shelters ceramides and diacylglycerol lipids inside its START domain and mediates the intracellular trafficking of ceramides and diacylglycerol lipids in a non-vesicular manner.<ref>PMID:14685229</ref> <ref>PMID:17591919</ref> <ref>PMID:18184806</ref> <ref>PMID:20036255</ref>
-The line below this paragraph, {{ABSTRACT_PUBMED_18184806}}, adds the Publication Abstract to the page
+== Evolutionary Conservation ==
-(as it appears on PubMed at http://www.pubmed.gov), where 18184806 is the PubMed ID number.
+[[Image:Consurf_key_small.gif|200px|right]]
--->
+Check<jmol>
-{{ABSTRACT_PUBMED_18184806}}
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e3/2e3p_consurf.spt"</scriptWhenChecked>
-==About this Structure==
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-E3P is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E3P OCA].
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
-==Reference==
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2e3p ConSurf].
-<ref group="xtra">PMID:18184806</ref><references group="xtra"/>
+<div style="clear:both"></div>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Hanada, K.]]
+[[Category: Large Structures]]
-[[Category: Kato, R.]]
+[[Category: Hanada K]]
-[[Category: Kudo, N.]]
+[[Category: Kato R]]
-[[Category: Kumagai, K.]]
+[[Category: Kudo N]]
-[[Category: Nishijima, M.]]
+[[Category: Kumagai K]]
-[[Category: Wakatsuki, S.]]
+[[Category: Nishijima M]]
-[[Category: Ceramide transfer]]
+[[Category: Wakatsuki S]]
-[[Category: Cert]]
-[[Category: Lipid transfer protein]]
-[[Category: Lipid transport]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 02:26:52 2009''

2e3p: Difference between revisions

Latest revision as of 13:48, 13 March 2024

Crystal structure of CERT START domain in complex with C16-cearmide (P1)

Structural highlights

Disease

Function

Evolutionary Conservation

References

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