3b6z: Difference between revisions

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{{Seed}}
[[Image:3b6z.png|left|200px]]


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==Lovastatin polyketide enoyl reductase (LovC) complexed with 2'-phosphoadenosyl isomer of crotonoyl-CoA==
The line below this paragraph, containing "STRUCTURE_3b6z", creates the "Structure Box" on the page.
<StructureSection load='3b6z' size='340' side='right'caption='[[3b6z]], [[Resolution|resolution]] 1.88&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3b6z]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aspergillus_terreus Aspergillus terreus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B6Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3B6Z FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.88&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO7:S-{(9R,13R,15S)-17-[(2R,3R,4R,5R)-5-(6-amino-9H-purin-9-yl)-3-hydroxy-4-(phosphonooxy)tetrahydrofuran-2-yl]-9,13,15-trihydroxy-10,10-dimethyl-13,15-dioxido-4,8-dioxo-12,14,16-trioxa-3,7-diaza-13,15-diphosphaheptadec-1-yl}(2E)-but-2-enethioate'>CO7</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
{{STRUCTURE_3b6z|  PDB=3b6z  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3b6z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b6z OCA], [https://pdbe.org/3b6z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3b6z RCSB], [https://www.ebi.ac.uk/pdbsum/3b6z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3b6z ProSAT]</span></td></tr>
 
</table>
===Lovastatin polyketide enoyl reductase (LovC) complexed with 2'-phosphoadenosyl isomer of crotonoyl-CoA===
== Function ==
 
[https://www.uniprot.org/uniprot/LOVC_ASPTE LOVC_ASPTE] Catalyzes the NADPH-dependent reduction of the unsaturated tetra-, penta- and heptaketide intermediates that arise during the LovB-mediated biosynthesis of the lovastatin nonaketide chain.<ref>PMID:10334994</ref> <ref>PMID:19900898</ref> <ref>PMID:22733743</ref>
 
== Evolutionary Conservation ==
==About this Structure==
[[Image:Consurf_key_small.gif|200px|right]]
3B6Z is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Aspergillus_terreus Aspergillus terreus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B6Z OCA].  
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b6/3b6z_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3b6z ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Aspergillus terreus]]
[[Category: Aspergillus terreus]]
[[Category: Ames, B D.]]
[[Category: Large Structures]]
[[Category: Ma, S M.]]
[[Category: Ames BD]]
[[Category: Smith, P T.]]
[[Category: Ma SM]]
[[Category: Tang, Y.]]
[[Category: Smith PT]]
[[Category: Tsai, S C.]]
[[Category: Tang Y]]
[[Category: Vederas, J C.]]
[[Category: Tsai S-C]]
[[Category: Wong, E W.]]
[[Category: Vederas JC]]
[[Category: Xie, X.]]
[[Category: Wong EW]]
[[Category: Medium-chain reductase]]
[[Category: Xie X]]
[[Category: Nadp-binding]]
[[Category: Oxidoreductase]]
[[Category: Rossmann fold]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 02:58:38 2009''
Retrieved from "https://proteopedia.org/3b6z"