2pla: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
 
(9 intermediate revisions by the same user not shown)
Line 1: Line 1:
{{Seed}}
[[Image:2pla.png|left|200px]]


<!--
==Crystal structure of human glycerol-3-phosphate dehydrogenase 1-like protein==
The line below this paragraph, containing "STRUCTURE_2pla", creates the "Structure Box" on the page.
<StructureSection load='2pla' size='340' side='right'caption='[[2pla]], [[Resolution|resolution]] 2.51&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2pla]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PLA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PLA FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.51&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
{{STRUCTURE_2pla|  PDB=2pla  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pla FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pla OCA], [https://pdbe.org/2pla PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pla RCSB], [https://www.ebi.ac.uk/pdbsum/2pla PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pla ProSAT]</span></td></tr>
 
</table>
===Crystal structure of human glycerol-3-phosphate dehydrogenase 1-like protein===
== Disease ==
 
[https://www.uniprot.org/uniprot/GPD1L_HUMAN GPD1L_HUMAN] Brugada syndrome. The disease is caused by mutations affecting the gene represented in this entry.  Disease susceptibility is associated with variations affecting the gene represented in this entry.
 
== Function ==
==About this Structure==
[https://www.uniprot.org/uniprot/GPD1L_HUMAN GPD1L_HUMAN] Plays a role in regulating cardiac sodium current; decreased enzymatic activity with resulting increased levels of glycerol 3-phosphate activating the DPD1L-dependent SCN5A phosphorylation pathway, may ultimately lead to decreased sodium current; cardiac sodium current may also be reduced due to alterations of NAD(H) balance induced by DPD1L.<ref>PMID:19666841</ref> <ref>PMID:19745168</ref>
2PLA is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PLA OCA].  
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pl/2pla_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2pla ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Arrowsmith, C H.]]
[[Category: Large Structures]]
[[Category: Bunkoczi, G.]]
[[Category: Arrowsmith CH]]
[[Category: Delft, F von.]]
[[Category: Bunkoczi G]]
[[Category: Edwards, A.]]
[[Category: Edwards A]]
[[Category: Hozjan, V.]]
[[Category: Hozjan V]]
[[Category: Kavanagh, K.]]
[[Category: Kavanagh K]]
[[Category: Oppermann, U.]]
[[Category: Oppermann U]]
[[Category: Papagrigoriou, E.]]
[[Category: Papagrigoriou E]]
[[Category: Pike, A C.W.]]
[[Category: Pike ACW]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Smee C]]
[[Category: Smee, C.]]
[[Category: Sundstrom M]]
[[Category: Sundstrom, M.]]
[[Category: Ugochukwu E]]
[[Category: Ugochukwu, E.]]
[[Category: Umeano C]]
[[Category: Umeano, C.]]
[[Category: Uppenberg J]]
[[Category: Uppenberg, J.]]
[[Category: Weigelt J]]
[[Category: Weigelt, J.]]
[[Category: Von Delft F]]
[[Category: Dehydrogenase]]
[[Category: Sgc]]
[[Category: Structural genomic]]
[[Category: Structural genomics consortium]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 03:23:19 2009''
Retrieved from "https://proteopedia.org/2pla"