1nkk: Difference between revisions

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{{Seed}}
[[Image:1nkk.png|left|200px]]


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==COMPLEX STRUCTURE OF HCMV PROTEASE AND A PEPTIDOMIMETIC INHIBITOR==
The line below this paragraph, containing "STRUCTURE_1nkk", creates the "Structure Box" on the page.
<StructureSection load='1nkk' size='340' side='right'caption='[[1nkk]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1nkk]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_betaherpesvirus_5 Human betaherpesvirus 5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NKK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NKK FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=CFT:TRIFLUOROMETHANE'>CFT</scene>, <scene name='pdbligand=DMH:N4,N4-DIMETHYL-ASPARAGINE'>DMH</scene>, <scene name='pdbligand=DMK:3,3-DIMETHYL+ASPARTIC+ACID'>DMK</scene></td></tr>
{{STRUCTURE_1nkk| PDB=1nkk |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nkk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nkk OCA], [https://pdbe.org/1nkk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nkk RCSB], [https://www.ebi.ac.uk/pdbsum/1nkk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nkk ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SCAF_HCMVA SCAF_HCMVA] Capsid scaffolding protein acts as a scaffold protein by binding major capsid protein UL86 in the cytoplasm, inducing the nuclear localization of both proteins. Multimerizes in the nucleus such as protein UL86 forms the icosahedral T=16 capsid. Autocatalytic cleavage releases the assembly protein, and subsequently abolishes interaction with major capsid protein UL86. Cleavages products are evicted from the capsid before or during DNA packaging (By similarity).  Assemblin is a protease essential for virion assembly in the nucleus. Catalyzes the cleavage of the assembly protein after complete capsid formation. Assemblin and cleavages products are evicted from the capsid before or during DNA packaging (By similarity).  Assembly protein plays a major role in capsid assembly. Acts as a scaffold protein by binding major capsid protein UL86. Multimerizes in the nucleus such as protein UL86 forms the icosahedral T=16 capsid. Cleaved by assemblin after capsid completion. The cleavages products are evicted from the capsid before or during DNA packaging (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nk/1nkk_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nkk ConSurf].
<div style="clear:both"></div>


===COMPLEX STRUCTURE OF HCMV PROTEASE AND A PEPTIDOMIMETIC INHIBITOR===
==See Also==
 
*[[Virus protease 3D structures|Virus protease 3D structures]]
 
__TOC__
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</StructureSection>
The line below this paragraph, {{ABSTRACT_PUBMED_12549906}}, adds the Publication Abstract to the page
[[Category: Human betaherpesvirus 5]]
(as it appears on PubMed at http://www.pubmed.gov), where 12549906 is the PubMed ID number.
[[Category: Large Structures]]
-->
[[Category: Bailey M]]
{{ABSTRACT_PUBMED_12549906}}
[[Category: Batra R]]
 
[[Category: Halmos T]]
==About this Structure==
[[Category: Khayat R]]
1NKK is a 8 chains structure of sequences from [http://en.wikipedia.org/wiki/Human_herpesvirus_5 Human herpesvirus 5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NKK OCA].
[[Category: Qian C]]
 
[[Category: Tong L]]
==Reference==
<ref group="xtra">PMID:12549906</ref><references group="xtra"/>
[[Category: Assemblin]]
[[Category: Human herpesvirus 5]]
[[Category: Bailey, M.]]
[[Category: Batra, R.]]
[[Category: Halmos, T.]]
[[Category: Khayat, R.]]
[[Category: Qian, C.]]
[[Category: Tong, L.]]
[[Category: Hydrolase]]
[[Category: Induced-fit]]
[[Category: Peptidomimetic inhibitor]]
[[Category: Protease]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 04:38:55 2009''
Retrieved from "https://proteopedia.org/1nkk"