1nf8: Difference between revisions

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{{Seed}}
[[Image:1nf8.png|left|200px]]


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==Crystal structure of PhzD protein active site mutant with substrate==
The line below this paragraph, containing "STRUCTURE_1nf8", creates the "Structure Box" on the page.
<StructureSection load='1nf8' size='340' side='right'caption='[[1nf8]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1nf8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NF8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NF8 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=ISC:(5S,6S)-5-[(1-CARBOXYETHENYL)OXY]-6-HYDROXYCYCLOHEXA-1,3-DIENE-1-CARBOXYLIC+ACID'>ISC</scene></td></tr>
{{STRUCTURE_1nf8|  PDB=1nf8  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nf8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nf8 OCA], [https://pdbe.org/1nf8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nf8 RCSB], [https://www.ebi.ac.uk/pdbsum/1nf8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nf8 ProSAT]</span></td></tr>
 
</table>
===Crystal structure of PhzD protein active site mutant with substrate===
== Function ==
 
[https://www.uniprot.org/uniprot/PHZD1_PSEAE PHZD1_PSEAE] Involved in the biosynthesis of the antibiotic phenazine, a nitrogen-containing heterocyclic molecule. PhzD1 (operon phzA1B1C1E1F1G1) has a role in the biosynthesis of the phenazine during planktonic growth (PubMed:23129634). Catalyzes the hydrolysis of the vinyl ether functional group of 2-amino-2-deoxyisochorismate (ADIC), yielding pyruvate and trans-2,3-dihydro-3-hydroxyanthranilic acid (DHHA) (PubMed:12741825, PubMed:23129634). Also able to act on isochorismate, chorismate and 4-amino-4-deoxychorismate (ADC) as substrates (PubMed:12741825).<ref>PMID:12741825</ref> <ref>PMID:23129634</ref> <ref>PMID:11591691</ref>
 
== Evolutionary Conservation ==
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    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nf/1nf8_consurf.spt"</scriptWhenChecked>
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==About this Structure==
  </jmolCheckbox>
1NF8 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NF8 OCA].  
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nf8 ConSurf].
 
<div style="clear:both"></div>
==Reference==
== References ==
<ref group="xtra">PMID:12741825</ref><references group="xtra"/>
<references/>
[[Category: Isochorismatase]]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Pseudomonas aeruginosa]]
[[Category: Pseudomonas aeruginosa]]
[[Category: Calabrese, K.]]
[[Category: Calabrese K]]
[[Category: Eisenstein, E.]]
[[Category: Eisenstein E]]
[[Category: Ladner, J E.]]
[[Category: Ladner JE]]
[[Category: Parsons, F.]]
[[Category: Parsons F]]
[[Category: Enzyme]]
[[Category: Isochorismatase]]
[[Category: Phenazine pathway]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 04:43:55 2009''
Retrieved from "https://proteopedia.org/1nf8"