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New page: left|200px<br /><applet load="2an1" size="450" color="white" frame="true" align="right" spinBox="true" caption="2an1, resolution 2.0Å" /> '''Structural Genomics, ...
 
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[[Image:2an1.gif|left|200px]]<br /><applet load="2an1" size="450" color="white" frame="true" align="right" spinBox="true"
caption="2an1, resolution 2.0&Aring;" />
'''Structural Genomics, The crystal structure of a putative kinase from Salmonella typhimurim LT2'''<br />


==About this Structure==
==Structural Genomics, The crystal structure of a putative kinase from Salmonella typhimurim LT2==
2AN1 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Salmonella_typhimurium Salmonella typhimurium]. Active as [http://en.wikipedia.org/wiki/NAD(+)_kinase NAD(+) kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.23 2.7.1.23] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2AN1 OCA].  
<StructureSection load='2an1' size='340' side='right'caption='[[2an1]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
[[Category: NAD(+) kinase]]
== Structural highlights ==
[[Category: Salmonella typhimurium]]
<table><tr><td colspan='2'>[[2an1]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium_str._LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AN1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AN1 FirstGlance]. <br>
[[Category: Single protein]]
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
[[Category: Collart, F.]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2an1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2an1 OCA], [https://pdbe.org/2an1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2an1 RCSB], [https://www.ebi.ac.uk/pdbsum/2an1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2an1 ProSAT], [https://www.topsan.org/Proteins/MCSG/2an1 TOPSAN]</span></td></tr>
[[Category: Holzle, D.]]
</table>
[[Category: Joachimiak, A.]]
== Function ==
[[Category: MCSG, Midwest.Center.for.Structural.Genomics.]]
[https://www.uniprot.org/uniprot/NADK_SALTY NADK_SALTY] Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. It can use ATP and other nucleoside triphosphates as a source of phosphorus. NADH can not replace NAD as a substrate.[HAMAP-Rule:MF_00361]<ref>PMID:16682646</ref>
[[Category: Zhang, R.]]
== Evolutionary Conservation ==
[[Category: Zhou, M.]]
[[Image:Consurf_key_small.gif|200px|right]]
[[Category: mcsg]]
Check<jmol>
[[Category: midwest center for structural genomics]]
  <jmolCheckbox>
[[Category: protein structure initiative]]
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/an/2an1_consurf.spt"</scriptWhenChecked>
[[Category: psi]]
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
[[Category: putative kinase]]
    <text>to colour the structure by Evolutionary Conservation</text>
[[Category: structural genomics]]
  </jmolCheckbox>
 
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2an1 ConSurf].
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 08:14:01 2007''
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]]
[[Category: Collart F]]
[[Category: Holzle D]]
[[Category: Joachimiak A]]
[[Category: Zhang R]]
[[Category: Zhou M]]
Retrieved from "https://proteopedia.org/2an1"