3b94: Difference between revisions

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{{Seed}}
[[Image:3b94.png|left|200px]]


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==Crystal structure of human GITRL==
The line below this paragraph, containing "STRUCTURE_3b94", creates the "Structure Box" on the page.
<StructureSection load='3b94' size='340' side='right'caption='[[3b94]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3b94]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B94 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3B94 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3b94 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b94 OCA], [https://pdbe.org/3b94 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3b94 RCSB], [https://www.ebi.ac.uk/pdbsum/3b94 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3b94 ProSAT]</span></td></tr>
{{STRUCTURE_3b94| PDB=3b94 |  SCENE= }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/TNF18_HUMAN TNF18_HUMAN] Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B.<ref>PMID:17449724</ref> <ref>PMID:18040044</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b9/3b94_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3b94 ConSurf].
<div style="clear:both"></div>


===Crystal structure of human GITRL===
==See Also==
 
*[[Tumor necrosis factor ligand superfamily 3D structures|Tumor necrosis factor ligand superfamily 3D structures]]
 
*[[Tumor necrosis factor receptor 3D structures|Tumor necrosis factor receptor 3D structures]]
==About this Structure==
== References ==
3B94 is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B94 OCA].
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Song, X M.]]
[[Category: Large Structures]]
[[Category: Zhou, Z C.]]
[[Category: Song XM]]
[[Category: Asymmetric trimer]]
[[Category: Zhou ZC]]
[[Category: Cytokine]]
[[Category: Glycoprotein]]
[[Category: Membrane]]
[[Category: P63 spacegroup]]
[[Category: Signal-anchor]]
[[Category: Symmetric trimer]]
[[Category: Tetramer of trimer]]
[[Category: Transmembrane]]
 
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Retrieved from "https://proteopedia.org/3b94"