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New page: left|200px<br /><applet load="2ani" size="450" color="white" frame="true" align="right" spinBox="true" caption="2ani, resolution 2.0Å" /> '''Crystal structure of ...
 
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[[Image:2ani.gif|left|200px]]<br /><applet load="2ani" size="450" color="white" frame="true" align="right" spinBox="true"
caption="2ani, resolution 2.0&Aring;" />
'''Crystal structure of the F127Y mutant of Ribonucleotide Reductase R2 from Chlamydia trachomatis'''<br />


==About this Structure==
==Crystal structure of the F127Y mutant of Ribonucleotide Reductase R2 from Chlamydia trachomatis==
2ANI is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Chlamydia_trachomatis Chlamydia trachomatis] with FE and PB as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Ribonucleoside-diphosphate_reductase Ribonucleoside-diphosphate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.4.1 1.17.4.1] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2ANI OCA].  
<StructureSection load='2ani' size='340' side='right'caption='[[2ani]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2ani]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Chlamydia_trachomatis Chlamydia trachomatis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ANI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ANI FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=PB:LEAD+(II)+ION'>PB</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ani FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ani OCA], [https://pdbe.org/2ani PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ani RCSB], [https://www.ebi.ac.uk/pdbsum/2ani PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ani ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RIR2_CHLTR RIR2_CHLTR] Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/an/2ani_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ani ConSurf].
<div style="clear:both"></div>
 
==See Also==
*[[Ribonucleotide reductase 3D structures|Ribonucleotide reductase 3D structures]]
__TOC__
</StructureSection>
[[Category: Chlamydia trachomatis]]
[[Category: Chlamydia trachomatis]]
[[Category: Ribonucleoside-diphosphate reductase]]
[[Category: Large Structures]]
[[Category: Single protein]]
[[Category: Hogbom M]]
[[Category: Hogbom, M.]]
[[Category: Nordlund P]]
[[Category: Nordlund, P.]]
[[Category: Stenmark P]]
[[Category: Stenmark, P.]]
[[Category: FE]]
[[Category: PB]]
[[Category: diiron]]
[[Category: radical]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 08:14:38 2007''
Retrieved from "https://proteopedia.org/2ani"