1u0m: Difference between revisions

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{{Seed}}
[[Image:1u0m.png|left|200px]]


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==Crystal Structure of 1,3,6,8-Tetrahydroxynaphthalene Synthase (THNS) from Streptomyces coelicolor A3(2): a Bacterial Type III Polyketide Synthase (PKS) Provides Insights into Enzymatic Control of Reactive Polyketide Intermediates==
The line below this paragraph, containing "STRUCTURE_1u0m", creates the "Structure Box" on the page.
<StructureSection load='1u0m' size='340' side='right'caption='[[1u0m]], [[Resolution|resolution]] 2.22&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1u0m]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_coelicolor_A3(2) Streptomyces coelicolor A3(2)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U0M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1U0M FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.22&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=15P:POLYETHYLENE+GLYCOL+(N=34)'>15P</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
{{STRUCTURE_1u0m|  PDB=1u0m  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1u0m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u0m OCA], [https://pdbe.org/1u0m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1u0m RCSB], [https://www.ebi.ac.uk/pdbsum/1u0m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1u0m ProSAT]</span></td></tr>
 
</table>
===Crystal Structure of 1,3,6,8-Tetrahydroxynaphthalene Synthase (THNS) from Streptomyces coelicolor A3(2): a Bacterial Type III Polyketide Synthase (PKS) Provides Insights into Enzymatic Control of Reactive Polyketide Intermediates===
== Function ==
 
[https://www.uniprot.org/uniprot/RPPA_STRCO RPPA_STRCO] Involved in the biosynthesis of melanin but also various secondary metabolites containing a naphthoquinone ring. Catalyzes the iterative condensation of five CoA-linked malonyl units to form a pentaketide intermediate. THNS subsequently catalyzes the dual intramolecular Claisen and aldol condensations of this linear intermediate to produce the fused ring of 1,3,6,8-tetrahydroxynaphthalene (THN).<ref>PMID:12905073</ref> <ref>PMID:15265863</ref>
 
== Evolutionary Conservation ==
<!--
[[Image:Consurf_key_small.gif|200px|right]]
The line below this paragraph, {{ABSTRACT_PUBMED_15265863}}, adds the Publication Abstract to the page
Check<jmol>
(as it appears on PubMed at http://www.pubmed.gov), where 15265863 is the PubMed ID number.
  <jmolCheckbox>
-->
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/u0/1u0m_consurf.spt"</scriptWhenChecked>
{{ABSTRACT_PUBMED_15265863}}
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 
    <text>to colour the structure by Evolutionary Conservation</text>
==About this Structure==
  </jmolCheckbox>
1U0M is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Bacteria Bacteria]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U0M OCA].  
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1u0m ConSurf].
 
<div style="clear:both"></div>
==Reference==
== References ==
<ref group="xtra">PMID:15265863</ref><references group="xtra"/>
<references/>
[[Category: Bacteria]]
__TOC__
[[Category: Austin, M B.]]
</StructureSection>
[[Category: Bowman, M E.]]
[[Category: Large Structures]]
[[Category: Ferrer, J L.]]
[[Category: Austin MB]]
[[Category: Izumikawa, M.]]
[[Category: Bowman ME]]
[[Category: Moore, B S.]]
[[Category: Ferrer JL]]
[[Category: Noel, J P.]]
[[Category: Izumikawa M]]
[[Category: Udwary, D W.]]
[[Category: Moore BS]]
[[Category: Alpha-beta-alpha-beta-alpha fold]]
[[Category: Noel JP]]
[[Category: Bacterial]]
[[Category: Udwary DW]]
[[Category: Catalytic triad]]
[[Category: Chalcone/stilbene synthase superfamily]]
[[Category: Chs-like]]
[[Category: Malonyl-coa]]
[[Category: Pk]]
[[Category: Tetrahydroxynaphthalene synthase]]
[[Category: Thiolase fold]]
[[Category: Thn]]
[[Category: Type iii polyketide synthase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 05:22:47 2009''

Latest revision as of 08:43, 14 February 2024

Crystal Structure of 1,3,6,8-Tetrahydroxynaphthalene Synthase (THNS) from Streptomyces coelicolor A3(2): a Bacterial Type III Polyketide Synthase (PKS) Provides Insights into Enzymatic Control of Reactive Polyketide Intermediates

1u0m, resolution 2.22Å

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