2obr: Difference between revisions

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{{Seed}}
[[Image:2obr.png|left|200px]]


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==Crystal Structures of P Domain of Norovirus VA387==
The line below this paragraph, containing "STRUCTURE_2obr", creates the "Structure Box" on the page.
<StructureSection load='2obr' size='340' side='right'caption='[[2obr]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2obr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Norovirus Norovirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OBR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OBR FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2obr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2obr OCA], [https://pdbe.org/2obr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2obr RCSB], [https://www.ebi.ac.uk/pdbsum/2obr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2obr ProSAT]</span></td></tr>
{{STRUCTURE_2obr|  PDB=2obr  |  SCENE=  }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q913Z3_9CALI Q913Z3_9CALI]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ob/2obr_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2obr ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Noroviruses are one of the major causes of nonbacterial gastroenteritis epidemics in humans. Recent studies on norovirus receptors show that different noroviruses recognize different human histo-blood group antigens (HBGAs), and eight receptor binding patterns of noroviruses have been identified. The P domain of the norovirus capsids is directly involved in this recognition. To determine the precise locations and receptor binding modes of HBGA carbohydrates on the viral capsids, a recombinant P protein of a GII-4 strain norovirus, VA387, was cocrystallized with synthetic type A or B trisaccharides. Based on complex crystal structures observed at a 2.0-A resolution, we demonstrated that the receptor binding site lies at the outermost end of the P domain and forms an extensive hydrogen-bonding network with the saccharide ligand. The A and B trisaccharides display similar binding modes, and the common fucose ring plays a key role in this interaction. The extensive interface between the two protomers in a P dimer also plays a crucial role in the formation of the receptor binding interface.


===Crystal Structures of P Domain of Norovirus VA387===
Structural basis for the recognition of blood group trisaccharides by norovirus.,Cao S, Lou Z, Tan M, Chen Y, Liu Y, Zhang Z, Zhang XC, Jiang X, Li X, Rao Z J Virol. 2007 Jun;81(11):5949-57. Epub 2007 Mar 28. PMID:17392366<ref>PMID:17392366</ref>


From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 2obr" style="background-color:#fffaf0;"></div>


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==See Also==
The line below this paragraph, {{ABSTRACT_PUBMED_17392366}}, adds the Publication Abstract to the page
*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
(as it appears on PubMed at http://www.pubmed.gov), where 17392366 is the PubMed ID number.
== References ==
-->
<references/>
{{ABSTRACT_PUBMED_17392366}}
__TOC__
 
</StructureSection>
==About this Structure==
[[Category: Large Structures]]
2OBR is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Norovirus Norovirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OBR OCA].
 
==Reference==
<ref group="xtra">PMID:17392366</ref><references group="xtra"/>
[[Category: Norovirus]]
[[Category: Norovirus]]
[[Category: Cao, S.]]
[[Category: Cao S]]
[[Category: Jiang, X.]]
[[Category: Jiang X]]
[[Category: Li, X.]]
[[Category: Li X]]
[[Category: Lou, Z.]]
[[Category: Lou Z]]
[[Category: Rao, Z.]]
[[Category: Rao Z]]
[[Category: Zhang, X C.]]
[[Category: Zhang XC]]
[[Category: Crystal structure]]
[[Category: Norovirus va387]]
[[Category: P domain]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 05:28:38 2009''

Latest revision as of 08:57, 25 October 2023

Crystal Structures of P Domain of Norovirus VA387

2obr, resolution 2.20Å

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