2gl8: Difference between revisions

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{{Seed}}
[[Image:2gl8.png|left|200px]]


<!--
==Human Retinoic acid receptor RXR-gamma ligand-binding domain==
The line below this paragraph, containing "STRUCTURE_2gl8", creates the "Structure Box" on the page.
<StructureSection load='2gl8' size='340' side='right'caption='[[2gl8]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2gl8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GL8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GL8 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gl8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gl8 OCA], [https://pdbe.org/2gl8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gl8 RCSB], [https://www.ebi.ac.uk/pdbsum/2gl8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gl8 ProSAT]</span></td></tr>
{{STRUCTURE_2gl8| PDB=2gl8 |  SCENE= }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/RXRG_HUMAN RXRG_HUMAN] Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gl/2gl8_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2gl8 ConSurf].
<div style="clear:both"></div>


===Human Retinoic acid receptor RXR-gamma ligand-binding domain===
==See Also==
 
*[[Retinoid X receptor 3D structures|Retinoid X receptor 3D structures]]
 
__TOC__
==About this Structure==
</StructureSection>
2GL8 is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GL8 OCA].
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Arrowsmith, C H.]]
[[Category: Large Structures]]
[[Category: Bochkarev, A.]]
[[Category: Arrowsmith CH]]
[[Category: Edwards, A M.]]
[[Category: Bochkarev A]]
[[Category: Loppnau, P.]]
[[Category: Edwards AM]]
[[Category: Min, J R.]]
[[Category: Loppnau P]]
[[Category: Plotnikov, A N.]]
[[Category: Min JR]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Plotnikov AN]]
[[Category: Schuetz, A.]]
[[Category: Schuetz A]]
[[Category: Sundstrom, M.]]
[[Category: Sundstrom M]]
[[Category: Weigelt, J.]]
[[Category: Weigelt J]]
[[Category: Nuclear receptor]]
[[Category: Sgc]]
[[Category: Structural genomic]]
[[Category: Structural genomics consortium]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 05:45:46 2009''
Retrieved from "https://proteopedia.org/2gl8"