1knc: Difference between revisions

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{{Seed}}
[[Image:1knc.png|left|200px]]


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==Structure of AhpD from Mycobacterium tuberculosis, a novel enzyme with thioredoxin-like activity.==
The line below this paragraph, containing "STRUCTURE_1knc", creates the "Structure Box" on the page.
<StructureSection load='1knc' size='340' side='right'caption='[[1knc]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1knc]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KNC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KNC FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
{{STRUCTURE_1knc|  PDB=1knc  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1knc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1knc OCA], [https://pdbe.org/1knc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1knc RCSB], [https://www.ebi.ac.uk/pdbsum/1knc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1knc ProSAT]</span></td></tr>
 
</table>
===Structure of AhpD from Mycobacterium tuberculosis, a novel enzyme with thioredoxin-like activity.===
== Function ==
 
[https://www.uniprot.org/uniprot/AHPD_MYCTU AHPD_MYCTU] Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity.<ref>PMID:10766746</ref> <ref>PMID:11799204</ref> <ref>PMID:12761216</ref>  Together with AhpC, DlaT and Lpd, constitutes an NADH-dependent peroxidase active against hydrogen and alkyl peroxides as well as serving as a peroxynitrite reductase, thus protecting the bacterium against reactive nitrogen intermediates and oxidative stress generated by the host immune system.<ref>PMID:10766746</ref> <ref>PMID:11799204</ref> <ref>PMID:12761216</ref>
 
== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kn/1knc_consurf.spt"</scriptWhenChecked>
{{ABSTRACT_PUBMED_11799204}}
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    <text>to colour the structure by Evolutionary Conservation</text>
==About this Structure==
  </jmolCheckbox>
1KNC is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KNC OCA].  
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1knc ConSurf].
 
<div style="clear:both"></div>
==Reference==
== References ==
<ref group="xtra">PMID:11799204</ref><references group="xtra"/>
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Bryk, R.]]
[[Category: Bryk R]]
[[Category: Erdjument-Bromage, H.]]
[[Category: Erdjument-Bromage H]]
[[Category: Lima, C D.]]
[[Category: Lima CD]]
[[Category: Nathan, C.]]
[[Category: Nathan C]]
[[Category: Tempst, P.]]
[[Category: Tempst P]]
[[Category: Ahpd]]
[[Category: Disulfide]]
[[Category: Lpd]]
[[Category: Peroxiredoxin]]
[[Category: Redox]]
[[Category: Thioredoxin]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 05:54:43 2009''
Retrieved from "https://proteopedia.org/1knc"