2fj9: Difference between revisions

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{{Seed}}
[[Image:2fj9.png|left|200px]]


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==High resolution crystal structure of the unliganded human ACBP==
The line below this paragraph, containing "STRUCTURE_2fj9", creates the "Structure Box" on the page.
<StructureSection load='2fj9' size='340' side='right'caption='[[2fj9]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2fj9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FJ9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FJ9 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PB:LEAD+(II)+ION'>PB</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
{{STRUCTURE_2fj9|  PDB=2fj9  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fj9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fj9 OCA], [https://pdbe.org/2fj9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fj9 RCSB], [https://www.ebi.ac.uk/pdbsum/2fj9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fj9 ProSAT]</span></td></tr>
 
</table>
===High resolution crystal structure of the unliganded human ACBP===
== Function ==
 
[https://www.uniprot.org/uniprot/ACBP_HUMAN ACBP_HUMAN] Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor.
 
== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
The line below this paragraph, {{ABSTRACT_PUBMED_17044054}}, adds the Publication Abstract to the page
Check<jmol>
(as it appears on PubMed at http://www.pubmed.gov), where 17044054 is the PubMed ID number.
  <jmolCheckbox>
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    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fj/2fj9_consurf.spt"</scriptWhenChecked>
{{ABSTRACT_PUBMED_17044054}}
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 
    <text>to colour the structure by Evolutionary Conservation</text>
==About this Structure==
  </jmolCheckbox>
2FJ9 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FJ9 OCA].  
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fj9 ConSurf].
 
<div style="clear:both"></div>
==Reference==
__TOC__
<ref group="xtra">PMID:17044054</ref><references group="xtra"/>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Aalten, D M.van.]]
[[Category: Large Structures]]
[[Category: Knudsen, J.]]
[[Category: Knudsen J]]
[[Category: Taskinen, J P.]]
[[Category: Taskinen JP]]
[[Category: Wierenga, R K.]]
[[Category: Wierenga RK]]
[[Category: Acbp]]
[[Category: Van Aalten DM]]
[[Category: Fatty acid metabolism]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 06:07:58 2009''
Retrieved from "https://proteopedia.org/2fj9"