2ic6: Difference between revisions

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{{Seed}}
[[Image:2ic6.png|left|200px]]


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==The Coiled-coil Domain (residues 1-75) Structure of the Sin Nombre Virus Nucleocapsid Protein==
The line below this paragraph, containing "STRUCTURE_2ic6", creates the "Structure Box" on the page.
<StructureSection load='2ic6' size='340' side='right'caption='[[2ic6]], [[Resolution|resolution]] 1.15&Aring;' scene=''>
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== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2ic6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Sin_Nombre_orthohantavirus Sin Nombre orthohantavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IC6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IC6 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.15&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ic6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ic6 OCA], [https://pdbe.org/2ic6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ic6 RCSB], [https://www.ebi.ac.uk/pdbsum/2ic6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ic6 ProSAT]</span></td></tr>
{{STRUCTURE_2ic6|  PDB=2ic6  |  SCENE=  }}
</table>
 
== Function ==
===The Coiled-coil Domain (residues 1-75) Structure of the Sin Nombre Virus Nucleocapsid Protein===
[https://www.uniprot.org/uniprot/NCAP_SINV NCAP_SINV] Encapsidates the genome protecting it from nucleases (Probable). The encapsidated genomic RNA is termed the nucleocapsid (NC) and serves as template for transcription and replication (Probable). The nucleocapsid has a left-handed helical structure (By similarity). As a trimer, specifically binds and acts as a chaperone to unwind the panhandle structure formed by the viral RNA (vRNA) termini (PubMed:15650206, PubMed:15254200, PubMed:21378500, PubMed:16971445, PubMed:25062117, PubMed:16775315). Involved in the transcription and replication initiation of vRNA by mediating primer annealing (PubMed:20164193). Plays a role in cap snatching by sequestering capped RNAs in P bodies for use by the viral RdRp during transcription initiation (PubMed:19047634). Substitutes for the cellular cap-binding complex (eIF4F) to preferentially facilitate the translation of capped mRNAs (PubMed:18971945, PubMed:25062117). Initiates the translation by specifically binding to the cap and 40S ribosomal subunit (PubMed:20844026, PubMed:20164193, PubMed:25062117). Prevents the viral glycoprotein N (Gn) from autophagy-dependent breakdown maybe by blocking autophagosome formation (By similarity). Inhibits host EIF2AK2/PKR dimerization to prevent PKR-induced translational shutdown in cells and thus the activation of the antiviral state (By similarity). Also displays sequence-unspecific DNA endonuclease activity (PubMed:27261891).[UniProtKB:O36307][UniProtKB:P05133]<ref>PMID:15254200</ref> <ref>PMID:15650206</ref> <ref>PMID:16775315</ref> <ref>PMID:16971445</ref> <ref>PMID:18971945</ref> <ref>PMID:19047634</ref> <ref>PMID:20164193</ref> <ref>PMID:20844026</ref> <ref>PMID:21378500</ref> <ref>PMID:25062117</ref> <ref>PMID:27261891</ref>
 
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
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{{ABSTRACT_PUBMED_17222867}}
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==About this Structure==
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ic6 ConSurf].
2IC6 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Sin_nombre_virus Sin nombre virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IC6 OCA].  
<div style="clear:both"></div>
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:17222867</ref><references group="xtra"/>
__TOC__
[[Category: Sin nombre virus]]
</StructureSection>
[[Category: Boudko, S P.]]
[[Category: Large Structures]]
[[Category: Rossmann, M G.]]
[[Category: Sin Nombre orthohantavirus]]
[[Category: Antiparallel coiled coil]]
[[Category: Boudko SP]]
[[Category: Bunyaviridae]]
[[Category: Rossmann MG]]
[[Category: Hantavirus]]
[[Category: Nucleocapsid protein]]
[[Category: Sin nombre virus]]
[[Category: Ssrna negative-strand viruse]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 06:15:36 2009''
Retrieved from "https://proteopedia.org/2ic6"