1o7t: Difference between revisions

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{{Seed}}
[[Image:1o7t.png|left|200px]]


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==Metal nanoclusters bound to the Ferric Binding Protein from Neisseria gonorrhoeae.==
The line below this paragraph, containing "STRUCTURE_1o7t", creates the "Structure Box" on the page.
<StructureSection load='1o7t' size='340' side='right'caption='[[1o7t]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1o7t]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Neisseria_gonorrhoeae Neisseria gonorrhoeae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O7T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1O7T FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HF3:SMALLEST+HF-OXO-PHOSPHATE+CLUSTER+HF3'>HF3</scene>, <scene name='pdbligand=HF5:HF+OXO+CLUSTER+HF5'>HF5</scene>, <scene name='pdbligand=PHF:HF-OXO-PHOSPHATE+CLUSTER+PHF'>PHF</scene></td></tr>
{{STRUCTURE_1o7t|  PDB=1o7t  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1o7t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o7t OCA], [https://pdbe.org/1o7t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1o7t RCSB], [https://www.ebi.ac.uk/pdbsum/1o7t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1o7t ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q50964_NEIGO Q50964_NEIGO]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o7/1o7t_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1o7t ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Transferrins transport Fe3+ and other metal ions in mononuclear-binding sites. We present the first evidence that a member of the transferrin superfamily is able to recognize multi-nuclear oxo-metal clusters, small mineral fragments that are the most abundant forms of many metals in the environment. We show that the ferric ion-binding protein from Neisseria gonorrhoeae (nFbp) readily binds clusters of Fe3+, Ti4+, Zr4+ or Hf4+ in solution. The 1.7 A resolution crystal structure of Hf-nFbp reveals three distinct types of clusters in an open, positively charged cleft between two hinged protein domains. A di-tyrosyl cluster nucleation motif (Tyr195-Tyr196) is situated at the bottom of this cleft and binds either a trinuclear oxo-Hf cluster, which is capped by phosphate, or a pentanuclear cluster, which in turn can be capped with phosphate. This first high-resolution structure of a protein-mineral interface suggests a novel metal-uptake mechanism and provides a model for protein-mediated mineralization/dissimilation, which plays a critical role in geochemical processes.


===METAL NANOCLUSTERS BOUND TO THE FERRIC BINDING PROTEIN FROM NEISSERIA GONORRHOEAE.===
A novel protein-mineral interface.,Alexeev D, Zhu H, Guo M, Zhong W, Hunter DJ, Yang W, Campopiano DJ, Sadler PJ Nat Struct Biol. 2003 Apr;10(4):297-302. PMID:12598891<ref>PMID:12598891</ref>


From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1o7t" style="background-color:#fffaf0;"></div>


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==See Also==
The line below this paragraph, {{ABSTRACT_PUBMED_12598891}}, adds the Publication Abstract to the page
*[[Ferric-binding protein|Ferric-binding protein]]
(as it appears on PubMed at http://www.pubmed.gov), where 12598891 is the PubMed ID number.
== References ==
-->
<references/>
{{ABSTRACT_PUBMED_12598891}}
__TOC__
 
</StructureSection>
==About this Structure==
[[Category: Large Structures]]
1O7T is a 9 chains structure of sequences from [http://en.wikipedia.org/wiki/Neisseria_gonorrhoeae Neisseria gonorrhoeae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O7T OCA].
 
==Reference==
<ref group="xtra">PMID:12598891</ref><references group="xtra"/>
[[Category: Neisseria gonorrhoeae]]
[[Category: Neisseria gonorrhoeae]]
[[Category: Alexeev, D.]]
[[Category: Alexeev D]]
[[Category: Campopiano, D J.]]
[[Category: Campopiano DJ]]
[[Category: Guo, M.]]
[[Category: Guo M]]
[[Category: Hunter, D J.B.]]
[[Category: Hunter DJB]]
[[Category: Sadler, P J.]]
[[Category: Sadler PJ]]
[[Category: Yang, W.]]
[[Category: Yang W]]
[[Category: Zhong, W.]]
[[Category: Zhong W]]
[[Category: Zu, H.]]
[[Category: Zu H]]
[[Category: Hafnium]]
[[Category: Metal-oxo cluster]]
[[Category: Periplasmic ferric binding protein]]
 
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Retrieved from "https://proteopedia.org/1o7t"