1yye: Difference between revisions
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< | ==Crystal structure of estrogen receptor beta complexed with way-202196== | ||
<StructureSection load='1yye' size='340' side='right'caption='[[1yye]], [[Resolution|resolution]] 2.03Å' scene=''> | |||
== Structural highlights == | |||
or the | <table><tr><td colspan='2'>[[1yye]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YYE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YYE FirstGlance]. <br> | ||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.03Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=196:3-(3-FLUORO-4-HYDROXYPHENYL)-7-HYDROXY-1-NAPHTHONITRILE'>196</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yye FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yye OCA], [https://pdbe.org/1yye PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yye RCSB], [https://www.ebi.ac.uk/pdbsum/1yye PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yye ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/ESR2_HUMAN ESR2_HUMAN] Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual. | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yy/1yye_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1yye ConSurf]. | |||
<div style="clear:both"></div> | |||
== | ==See Also== | ||
*[[Estrogen receptor 3D structures|Estrogen receptor 3D structures]] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Edsall Jr RJ]] | |||
[[Category: Jr | [[Category: Harris HA]] | ||
[[Category: | [[Category: Henderson RA]] | ||
[[Category: | [[Category: Keith Jr JC]] | ||
[[Category: | [[Category: Manas ES]] | ||
[[Category: | [[Category: Mewshaw RE]] | ||
[[Category: | [[Category: Xu ZB]] | ||
[[Category: | [[Category: Yang C]] | ||
[[Category: | |||
Latest revision as of 09:01, 14 February 2024
Crystal structure of estrogen receptor beta complexed with way-202196
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