2qme: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,615 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,615 edits
No edit summary
 
(8 intermediate revisions by the same user not shown)
Line 1: Line 1:
{{Seed}}
[[Image:2qme.png|left|200px]]


<!--
==Crystal structure of human RAC3 in complex with CRIB domain of human p21-activated kinase 1 (PAK1)==
The line below this paragraph, containing "STRUCTURE_2qme", creates the "Structure Box" on the page.
<StructureSection load='2qme' size='340' side='right'caption='[[2qme]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2qme]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QME OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QME FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GCP:PHOSPHOMETHYLPHOSPHONIC+ACID+GUANYLATE+ESTER'>GCP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
{{STRUCTURE_2qme| PDB=2qme |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qme FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qme OCA], [https://pdbe.org/2qme PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qme RCSB], [https://www.ebi.ac.uk/pdbsum/2qme PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qme ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RAC3_HUMAN RAC3_HUMAN] Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles.<ref>PMID:11956649</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qm/2qme_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2qme ConSurf].
<div style="clear:both"></div>


===Crystal structure of human RAC3 in complex with CRIB domain of human p21-activated kinase 1 (PAK1)===
==See Also==
 
*[[Rac 3D structures|Rac 3D structures]]
 
*[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]]
==About this Structure==
== References ==
2QME is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QME OCA].
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C H.]]
[[Category: Arrowsmith CH]]
[[Category: Bunkoczi, G.]]
[[Category: Bunkoczi G]]
[[Category: Burgess-Brown, N.]]
[[Category: Burgess-Brown N]]
[[Category: Delft, F von.]]
[[Category: Doyle D]]
[[Category: Doyle, D.]]
[[Category: Edwards A]]
[[Category: Edwards, A.]]
[[Category: Elkins JM]]
[[Category: Elkins, J M.]]
[[Category: Knapp S]]
[[Category: Knapp, S.]]
[[Category: Sundstrom M]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Ugochukwu E]]
[[Category: Sundstrom, M.]]
[[Category: Weigelt J]]
[[Category: Ugochukwu, E.]]
[[Category: Yang X]]
[[Category: Weigelt, J.]]
[[Category: Von Delft F]]
[[Category: Yang, X.]]
[[Category: Allosteric enzyme]]
[[Category: Alternative splicing]]
[[Category: Apoptosis]]
[[Category: Atp-binding]]
[[Category: Cell junction]]
[[Category: Cell projection]]
[[Category: Crib]]
[[Category: Cytoplasm]]
[[Category: Gtp-binding]]
[[Category: Gtpase rac3]]
[[Category: Kinase]]
[[Category: Lipoprotein]]
[[Category: Membrane]]
[[Category: Methylation]]
[[Category: Nucleotide-binding]]
[[Category: P21 rac]]
[[Category: Phosphorylation]]
[[Category: Prenylation]]
[[Category: Ras-related c3 botulinum toxin substrate 3]]
[[Category: Serine/threonine-protein kinase]]
[[Category: Sgc]]
[[Category: Signaling protein]]
[[Category: Signaling protein/transferase complex]]
[[Category: Small gtp binding protein]]
[[Category: Structural genomic]]
[[Category: Structural genomics consortium]]
[[Category: Transferase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 08:08:04 2009''
Retrieved from "https://proteopedia.org/2qme"