1sco: Difference between revisions

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{{Seed}}
[[Image:1sco.png|left|200px]]


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==SCORPION TOXIN (OSK1 TOXIN) WITH HIGH AFFINITY FOR SMALL CONDUCTANCE CA(2+)-ACTIVATED K+ CHANNEL IN NEUROBLASTOMA-X-GLUOMA NG 108-15 HYBRID CELLS, NMR, 30 STRUCTURES==
The line below this paragraph, containing "STRUCTURE_1sco", creates the "Structure Box" on the page.
<StructureSection load='1sco' size='340' side='right'caption='[[1sco]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1sco]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Orthochirus_scrobiculosus Orthochirus scrobiculosus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SCO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SCO FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sco FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sco OCA], [https://pdbe.org/1sco PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sco RCSB], [https://www.ebi.ac.uk/pdbsum/1sco PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sco ProSAT]</span></td></tr>
{{STRUCTURE_1sco| PDB=1sco |  SCENE= }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/KAX37_ORTSC KAX37_ORTSC] Blocks voltage-gated potassium channels Kv1.1/KCNA1 (IC(50)=0.6nM), Kv1.2/KCNA2 (IC(50)=5.4nM), Kv1.3/KCNA3 (IC(50)=0.014nM) potently, and moderately block intermediate conductance calcium-activated potassium channels KCa3.1/KCNN4 (IC(50)=225nM). At high concentration (2 mM), is also active on Kv1.6/KCNA6 and Shaker IR.[REFERENCE:1]<ref>PMID:15588251</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sc/1sco_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1sco ConSurf].
<div style="clear:both"></div>


===SCORPION TOXIN (OSK1 TOXIN) WITH HIGH AFFINITY FOR SMALL CONDUCTANCE CA(2+)-ACTIVATED K+ CHANNEL IN NEUROBLASTOMA-X-GLUOMA NG 108-15 HYBRID CELLS, NMR, 30 STRUCTURES===
==See Also==
 
*[[Potassium channel toxin 3D structures|Potassium channel toxin 3D structures]]
 
== References ==
<!--
<references/>
The line below this paragraph, {{ABSTRACT_PUBMED_9063870}}, adds the Publication Abstract to the page
__TOC__
(as it appears on PubMed at http://www.pubmed.gov), where 9063870 is the PubMed ID number.
</StructureSection>
-->
[[Category: Large Structures]]
{{ABSTRACT_PUBMED_9063870}}
 
==About this Structure==
1SCO is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Orthochirus_scrobiculosus Orthochirus scrobiculosus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SCO OCA].
 
==Reference==
<ref group="xtra">PMID:9063870</ref><references group="xtra"/>
[[Category: Orthochirus scrobiculosus]]
[[Category: Orthochirus scrobiculosus]]
[[Category: Arseniev, A S.]]
[[Category: Arseniev AS]]
[[Category: Grishin, E V.]]
[[Category: Grishin EV]]
[[Category: Jaravine, V A.]]
[[Category: Jaravine VA]]
[[Category: Nolde, D E.]]
[[Category: Nolde DE]]
[[Category: Pluzhnikov, K A.]]
[[Category: Pluzhnikov KA]]
[[Category: Potassium channel inhibitor]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 09:16:10 2009''
Retrieved from "https://proteopedia.org/1sco"