2bec: Difference between revisions

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{{Seed}}
[[Image:2bec.png|left|200px]]


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==Crystal structure of CHP2 in complex with its binding region in NHE1 and insights into the mechanism of pH regulation==
The line below this paragraph, containing "STRUCTURE_2bec", creates the "Structure Box" on the page.
<StructureSection load='2bec' size='340' side='right'caption='[[2bec]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2bec]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BEC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BEC FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=YT3:YTTRIUM+(III)+ION'>YT3</scene></td></tr>
{{STRUCTURE_2bec|  PDB=2bec  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bec FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bec OCA], [https://pdbe.org/2bec PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bec RCSB], [https://www.ebi.ac.uk/pdbsum/2bec PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bec ProSAT]</span></td></tr>
 
</table>
===Crystal structure of CHP2 in complex with its binding region in NHE1 and insights into the mechanism of pH regulation===
== Function ==
 
[https://www.uniprot.org/uniprot/CHP2_HUMAN CHP2_HUMAN] Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation-induced death. Also plays a role in the regulation of cell proliferation and tumor growth by increasing the phosphatase activity of PPP3CA in a calcium-dependent manner. Activator of the calcineurin/NFAT signaling pathway. Involved in the cytoplasmic translocation of the transcription factor NFATC3 to the nucleus.<ref>PMID:12226101</ref> <ref>PMID:18815128</ref>  
 
== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/be/2bec_consurf.spt"</scriptWhenChecked>
{{ABSTRACT_PUBMED_16710297}}
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    <text>to colour the structure by Evolutionary Conservation</text>
==About this Structure==
  </jmolCheckbox>
2BEC is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BEC OCA].  
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2bec ConSurf].
 
<div style="clear:both"></div>
==Reference==
== References ==
<ref group="xtra">PMID:16710297</ref><references group="xtra"/>
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Ammar, Y Ben.]]
[[Category: Large Structures]]
[[Category: Hisamitsu, T.]]
[[Category: Ben Ammar Y]]
[[Category: Mori, H.]]
[[Category: Hisamitsu T]]
[[Category: Takeda, S.]]
[[Category: Mori H]]
[[Category: Wakabayashi, S.]]
[[Category: Takeda S]]
[[Category: Calcineurin-homologous protein]]
[[Category: Wakabayashi S]]
[[Category: Calcium-binding protein]]
[[Category: Nhe1 regulating protein]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 09:20:56 2009''
Retrieved from "https://proteopedia.org/2bec"