1sqj: Difference between revisions

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{{Seed}}
[[Image:1sqj.png|left|200px]]


<!--
==Crystal Structure Analysis of Oligoxyloglucan reducing-end-specific cellobiohydrolase (OXG-RCBH)==
The line below this paragraph, containing "STRUCTURE_1sqj", creates the "Structure Box" on the page.
<StructureSection load='1sqj' size='340' side='right'caption='[[1sqj]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1sqj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Geotrichum_sp._M128 Geotrichum sp. M128]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SQJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SQJ FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sqj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sqj OCA], [https://pdbe.org/1sqj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sqj RCSB], [https://www.ebi.ac.uk/pdbsum/1sqj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sqj ProSAT]</span></td></tr>
{{STRUCTURE_1sqj|  PDB=1sqj  |  SCENE=  }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/CBHRE_GEOS1 CBHRE_GEOS1]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sq/1sqj_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1sqj ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Oligoxyloglucan reducing-end-specific cellobiohydrolase (OXG-RCBH; EC 3.2.1.150) is an exoglucanase that recognizes the reducing end of oligoxyloglucan and releases two glucosyl residue segments from the main chain. The X-ray crystal structure of OXG-RCBH determined at 2.2 A resolution reveals a unique feature of this enzyme; OXG-RCBH consists of a tandem repeat of two similar domains, which are both folded into seven-bladed beta-propeller structures. The sequence alignment of the propeller blades, based on the structure, indicates that a weak repeat of the amino acid sequence occurred seven times to construct each domain. There is a cleft that can accommodate the substrate oligosaccharide between the two domains, which is a putative substrate binding subsite. Mutation of either Asp35 or Asp465, located in the putative catalytic center, to Asn resulted in a protein with no detectable catalytic activity, indicating the critical role of these amino acids in catalysis.


===Crystal Structure Analysis of Oligoxyloglucan reducing-end-specific cellobiohydrolase (OXG-RCBH)===
Tandem repeat of a seven-bladed beta-propeller domain in oligoxyloglucan reducing-end-specific cellobiohydrolase.,Yaoi K, Kondo H, Noro N, Suzuki M, Tsuda S, Mitsuishi Y Structure. 2004 Jul;12(7):1209-17. PMID:15242597<ref>PMID:15242597</ref>


From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1sqj" style="background-color:#fffaf0;"></div>


<!--
==See Also==
The line below this paragraph, {{ABSTRACT_PUBMED_15242597}}, adds the Publication Abstract to the page
*[[Cellobiohydrolase 3D structures|Cellobiohydrolase 3D structures]]
(as it appears on PubMed at http://www.pubmed.gov), where 15242597 is the PubMed ID number.
== References ==
-->
<references/>
{{ABSTRACT_PUBMED_15242597}}
__TOC__
 
</StructureSection>
==About this Structure==
[[Category: Geotrichum sp. M128]]
1SQJ is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Geotrichum_sp._m128 Geotrichum sp. m128]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SQJ OCA].
[[Category: Large Structures]]
 
[[Category: Kondo H]]
==Reference==
[[Category: Mitsuishi Y]]
<ref group="xtra">PMID:15242597</ref><ref group="xtra">PMID:12374797</ref><ref group="xtra">PMID:14501131</ref><references group="xtra"/>
[[Category: Noro N]]
[[Category: Geotrichum sp. m128]]
[[Category: Suzuki M]]
[[Category: Oligoxyloglucan reducing-end-specific cellobiohydrolase]]
[[Category: Tsuda S]]
[[Category: Kondo, H.]]
[[Category: Yaoi K]]
[[Category: Mitsuishi, Y.]]
[[Category: Noro, N.]]
[[Category: Suzuki, M.]]
[[Category: Tsuda, S.]]
[[Category: Yaoi, K.]]
[[Category: Beta-propeller]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 09:26:09 2009''

Latest revision as of 04:53, 17 October 2024

Crystal Structure Analysis of Oligoxyloglucan reducing-end-specific cellobiohydrolase (OXG-RCBH)

1sqj, resolution 2.20Å

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