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New page: left|200px<br /><applet load="2btv" size="450" color="white" frame="true" align="right" spinBox="true" caption="2btv, resolution 3.5Å" /> '''ATOMIC MODEL FOR BLUE...
 
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[[Image:2btv.gif|left|200px]]<br /><applet load="2btv" size="450" color="white" frame="true" align="right" spinBox="true"
caption="2btv, resolution 3.5&Aring;" />
'''ATOMIC MODEL FOR BLUETONGUE VIRUS (BTV) CORE'''<br />


==Overview==
==ATOMIC MODEL FOR BLUETONGUE VIRUS (BTV) CORE==
The structure of the core particle of bluetongue virus has been determined, by X-ray crystallography at a resolution approaching 3.5 A. This, transcriptionally active compartment, 700 A in diameter, represents the, largest molecular structure determined in such detail. The atomic, structure indicates how approximately 1,000 protein components, self-assemble, using both the classical mechanism of quasi-equivalent, contacts, which are achieved through triangulation, and a different, method, which we term geometrical quasi-equivalence.
<SX load='2btv' size='340' side='right' viewer='molstar' caption='[[2btv]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2btv]] is a 15 chain structure with sequence from [https://en.wikipedia.org/wiki/Bluetongue_virus_(serotype_1_/_isolate_South_Africa) Bluetongue virus (serotype 1 / isolate South Africa)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BTV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BTV FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2btv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2btv OCA], [https://pdbe.org/2btv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2btv RCSB], [https://www.ebi.ac.uk/pdbsum/2btv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2btv ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/VP3_BTV1S VP3_BTV1S] The VP3 protein is one of the five proteins (with VP1, VP4, VP6 and VP7) which form the inner capsid of the virus.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bt/2btv_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2btv ConSurf].
<div style="clear:both"></div>


==About this Structure==
==See Also==
2BTV is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Bluetongue_virus Bluetongue virus]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2BTV OCA].
*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
 
__TOC__
==Reference==
</SX>
The atomic structure of the bluetongue virus core., Grimes JM, Burroughs JN, Gouet P, Diprose JM, Malby R, Zientara S, Mertens PP, Stuart DI, Nature. 1998 Oct 1;395(6701):470-8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9774103 9774103]
[[Category: Large Structures]]
[[Category: Bluetongue virus]]
[[Category: Burroughs JN]]
[[Category: Protein complex]]
[[Category: Diprose JM]]
[[Category: Burroughs, J.N.]]
[[Category: Gouet P]]
[[Category: Diprose, J.M.]]
[[Category: Grimes JM]]
[[Category: Gouet, P.]]
[[Category: Malby R]]
[[Category: Grimes, J.M.]]
[[Category: Mertens PPC]]
[[Category: Malby, R.]]
[[Category: Stuart DI]]
[[Category: Mertens, P.P.C.]]
[[Category: Zientras S]]
[[Category: Stuart, D.I.]]
[[Category: Zientras, S.]]
[[Category: icosahedral virus]]
[[Category: virus/viral protein]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 08:55:02 2007''

Latest revision as of 09:17, 14 February 2024

ATOMIC MODEL FOR BLUETONGUE VIRUS (BTV) CORE

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