2jeo: Difference between revisions

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{{Seed}}
[[Image:2jeo.png|left|200px]]


<!--
==Crystal structure of human uridine-cytidine kinase 1==
The line below this paragraph, containing "STRUCTURE_2jeo", creates the "Structure Box" on the page.
<StructureSection load='2jeo' size='340' side='right'caption='[[2jeo]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2jeo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JEO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JEO FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jeo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jeo OCA], [https://pdbe.org/2jeo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jeo RCSB], [https://www.ebi.ac.uk/pdbsum/2jeo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jeo ProSAT]</span></td></tr>
{{STRUCTURE_2jeo|  PDB=2jeo  |  SCENE= }}
</table>
 
== Function ==
===CRYSTAL STRUCTURE OF HUMAN URIDINE-CYTIDINE KINASE 1===
[https://www.uniprot.org/uniprot/UCK1_HUMAN UCK1_HUMAN] Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate (PubMed:11306702). Does not phosphorylate deoxyribonucleosides or purine ribonucleosides (PubMed:11306702). Can use ATP or GTP as a phosphate donor (PubMed:11306702). Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine, and N(4)-anisoylcytidine (PubMed:11306702).<ref>PMID:11306702</ref>
 
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
==About this Structure==
Check<jmol>
2JEO is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JEO OCA].  
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/je/2jeo_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jeo ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Uridine kinase]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C.]]
[[Category: Arrowsmith C]]
[[Category: Berg, S Van Den.]]
[[Category: Berglund H]]
[[Category: Berglund, H.]]
[[Category: Busam R]]
[[Category: Busam, R.]]
[[Category: Collins R]]
[[Category: Collins, R.]]
[[Category: Edwards A]]
[[Category: Edwards, A.]]
[[Category: Ericsson UB]]
[[Category: Ericsson, U B.]]
[[Category: Flodin S]]
[[Category: Flodin, S.]]
[[Category: Flores A]]
[[Category: Flores, A.]]
[[Category: Graslund S]]
[[Category: Graslund, S.]]
[[Category: Hallberg BM]]
[[Category: Hallberg, B M.]]
[[Category: Hammarstrom M]]
[[Category: Hammarstrom, M.]]
[[Category: Hogbom M]]
[[Category: Hogbom, M.]]
[[Category: Holmberg Schiavone L]]
[[Category: Johansson, I.]]
[[Category: Johansson I]]
[[Category: Karlberg, T.]]
[[Category: Karlberg T]]
[[Category: Kosinska, U.]]
[[Category: Kosinska U]]
[[Category: Kotenyova, T.]]
[[Category: Kotenyova T]]
[[Category: Moche, M.]]
[[Category: Moche M]]
[[Category: Nilsson, M E.P.]]
[[Category: Nilsson MEP]]
[[Category: Nordlund, P.]]
[[Category: Nordlund P]]
[[Category: Nyman, T.]]
[[Category: Nyman T]]
[[Category: Ogg, D.]]
[[Category: Ogg D]]
[[Category: Persson, C.]]
[[Category: Persson C]]
[[Category: Sagemark, J.]]
[[Category: Sagemark J]]
[[Category: Schiavone, L Holmberg.]]
[[Category: Stenmark P]]
[[Category: Stenmark, P.]]
[[Category: Sundstrom M]]
[[Category: Sundstrom, M.]]
[[Category: Thorsell AG]]
[[Category: Thorsell, A G.]]
[[Category: Uppenberg J]]
[[Category: Uppenberg, J.]]
[[Category: Uppsten M]]
[[Category: Uppsten, M.]]
[[Category: Weigelt J]]
[[Category: Weigelt, J.]]
[[Category: Welin M]]
[[Category: Welin, M.]]
[[Category: Van den Berg S]]
[[Category: Atp-binding]]
[[Category: Kinase]]
[[Category: Nucleoside kinase]]
[[Category: Nucleotide-binding]]
[[Category: Transferase]]
[[Category: Uck]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 09:46:49 2009''
Retrieved from "https://proteopedia.org/2jeo"