2bvb: Difference between revisions
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New page: left|200px<br /><applet load="2bvb" size="450" color="white" frame="true" align="right" spinBox="true" caption="2bvb" /> '''THE C-TERMINAL DOMAIN FROM MICRONEMAL PROTEI... |
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== | ==The C-terminal domain from Micronemal Protein 1 (MIC1) from Toxoplasma Gondii== | ||
Immediately prior to invasion Toxoplasma gondii tachyzoites release a | <StructureSection load='2bvb' size='340' side='right'caption='[[2bvb]]' scene=''> | ||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2bvb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BVB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BVB FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 1 model</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bvb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bvb OCA], [https://pdbe.org/2bvb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bvb RCSB], [https://www.ebi.ac.uk/pdbsum/2bvb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bvb ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/MIC1_TOXGO MIC1_TOXGO] Adhesin. Required for attachment of the parasite to the host cell prior to invasion. Ensures correct folding of MIC6 and transport of the MIC6-MIC1-MIC4 complex into the micronemes.<ref>PMID:11447133</ref> <ref>PMID:11157983</ref> <ref>PMID:16166092</ref> <ref>PMID:17491595</ref> <ref>PMID:9027753</ref> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Immediately prior to invasion Toxoplasma gondii tachyzoites release a large number of micronemal proteins (TgMICs) that participate in host cell attachment and penetration. The TgMIC4-MIC1-MIC6 complex was the first to be identified in T. gondii and has been recently shown to be critical in invasion. This study establishes that the N-terminal thrombospondin type I repeat-like domains (TSR1-like) from TgMIC1 function as an independent adhesin as well as promoting association with TgMIC4. Using the newly solved three-dimensional structure of the C-terminal domain of TgMIC1 we have identified a novel Galectin-like fold that does not possess carbohydrate binding properties and redefines the architecture of TgMIC1. Instead, the TgMIC1 Galectin-like domain interacts and stabilizes TgMIC6, which provides the basis for a highly specific quality control mechanism for successful exit from the early secretory compartments and for subsequent trafficking of the complex to the micronemes. | |||
A novel galectin-like domain from Toxoplasma gondii micronemal protein 1 assists the folding, assembly, and transport of a cell adhesion complex.,Saouros S, Edwards-Jones B, Reiss M, Sawmynaden K, Cota E, Simpson P, Dowse TJ, Jakle U, Ramboarina S, Shivarattan T, Matthews S, Soldati-Favre D J Biol Chem. 2005 Nov 18;280(46):38583-91. Epub 2005 Sep 15. PMID:16166092<ref>PMID:16166092</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
[[Category: | <div class="pdbe-citations 2bvb" style="background-color:#fffaf0;"></div> | ||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Toxoplasma gondii]] | [[Category: Toxoplasma gondii]] | ||
[[Category: Cota | [[Category: Cota E]] | ||
[[Category: Dowse | [[Category: Dowse TJ]] | ||
[[Category: Edwards-Jones | [[Category: Edwards-Jones B]] | ||
[[Category: Jakle | [[Category: Jakle U]] | ||
[[Category: Matthews | [[Category: Matthews S]] | ||
[[Category: Ramboarina | [[Category: Ramboarina S]] | ||
[[Category: Reiss | [[Category: Reiss M]] | ||
[[Category: Saouros | [[Category: Saouros S]] | ||
[[Category: Sawmynaden | [[Category: Sawmynaden K]] | ||
[[Category: Shivarattan | [[Category: Shivarattan T]] | ||
[[Category: Simpson | [[Category: Simpson P]] | ||
[[Category: Soldati-Favre | [[Category: Soldati-Favre D]] | ||
Latest revision as of 09:02, 6 November 2024
The C-terminal domain from Micronemal Protein 1 (MIC1) from Toxoplasma Gondii
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