1m2z: Difference between revisions

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{{Seed}}
[[Image:1m2z.png|left|200px]]


<!--
==Crystal structure of a dimer complex of the human glucocorticoid receptor ligand-binding domain bound to dexamethasone and a TIF2 coactivator motif==
The line below this paragraph, containing "STRUCTURE_1m2z", creates the "Structure Box" on the page.
<StructureSection load='1m2z' size='340' side='right'caption='[[1m2z]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1m2z]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M2Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1M2Z FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=DEX:DEXAMETHASONE'>DEX</scene></td></tr>
{{STRUCTURE_1m2z| PDB=1m2z |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1m2z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m2z OCA], [https://pdbe.org/1m2z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1m2z RCSB], [https://www.ebi.ac.uk/pdbsum/1m2z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1m2z ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/GCR_HUMAN GCR_HUMAN] Defects in NR3C1 are a cause of glucocorticoid resistance (GCRES) [MIM:[https://omim.org/entry/138040 138040]; also known as cortisol resistance. It is a hypertensive, hyperandrogenic disorder characterized by increased serum cortisol concentrations. Inheritance is autosomal dominant.<ref>PMID:12050230</ref> <ref>PMID:1704018</ref> <ref>PMID:7683692</ref> <ref>PMID:11589680</ref> <ref>PMID:11701741</ref>
== Function ==
[https://www.uniprot.org/uniprot/GCR_HUMAN GCR_HUMAN] Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. Plays a significant role in transactivation.<ref>PMID:21664385</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m2/1m2z_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1m2z ConSurf].
<div style="clear:both"></div>


===Crystal structure of a dimer complex of the human glucocorticoid receptor ligand-binding domain bound to dexamethasone and a TIF2 coactivator motif===
==See Also==
 
*[[Glucocorticoid receptor|Glucocorticoid receptor]]
 
*[[Glucocorticoid receptor 3D structures|Glucocorticoid receptor 3D structures]]
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== References ==
The line below this paragraph, {{ABSTRACT_PUBMED_12151000}}, adds the Publication Abstract to the page
<references/>
(as it appears on PubMed at http://www.pubmed.gov), where 12151000 is the PubMed ID number.
__TOC__
-->
</StructureSection>
{{ABSTRACT_PUBMED_12151000}}
 
==About this Structure==
1M2Z is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M2Z OCA].
 
==Reference==
<ref group="xtra">PMID:12151000</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Apolito, C J.]]
[[Category: Large Structures]]
[[Category: Bledsoe, R B.]]
[[Category: Apolito CJ]]
[[Category: Consler, T G.]]
[[Category: Bledsoe RB]]
[[Category: Delves, C J.]]
[[Category: Consler TG]]
[[Category: Lambert, M H.]]
[[Category: Delves CJ]]
[[Category: Mckee, D D.]]
[[Category: Lambert MH]]
[[Category: Montana, V G.]]
[[Category: Mckee DD]]
[[Category: Moore, J T.]]
[[Category: Montana VG]]
[[Category: Parks, D J.]]
[[Category: Moore JT]]
[[Category: Pearce, K H.]]
[[Category: Parks DJ]]
[[Category: Stanley, T B.]]
[[Category: Pearce KH]]
[[Category: Stewart, E L.]]
[[Category: Stanley TB]]
[[Category: Willson, T M.]]
[[Category: Stewart EL]]
[[Category: Xu, H E.]]
[[Category: Willson TM]]
[[Category: Charge clamp]]
[[Category: Xu HE]]
[[Category: Coactivator]]
[[Category: Dexamethasone]]
[[Category: Dimer interface]]
[[Category: Glucocorticoid receptor]]
[[Category: Hormone binding pocket]]
[[Category: Tif2]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 10:43:23 2009''
Retrieved from "https://proteopedia.org/1m2z"