2v7n: Difference between revisions

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{{Seed}}
[[Image:2v7n.png|left|200px]]


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==Unusual twinning in crystals of the CitS binding antibody Fab fragment f3p4==
The line below this paragraph, containing "STRUCTURE_2v7n", creates the "Structure Box" on the page.
<StructureSection load='2v7n' size='340' side='right'caption='[[2v7n]], [[Resolution|resolution]] 1.92&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2v7n]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V7N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V7N FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.92&#8491;</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v7n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v7n OCA], [https://pdbe.org/2v7n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v7n RCSB], [https://www.ebi.ac.uk/pdbsum/2v7n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v7n ProSAT]</span></td></tr>
{{STRUCTURE_2v7n|  PDB=2v7n  |  SCENE=  }}
</table>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v7/2v7n_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2v7n ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The structure of the antibody Fab fragment f3p4, which was selected from a subset of the synthetic HuCAL antibody library to bind the sodium citrate symporter CitS, is described at 1.92 A resolution. Comparison with computational models revealed deviations in a few framework positions and in the binding loops. The crystals belong to space group P2(1)2(1)2 and contain four molecules in the asymmetric unit, with unit-cell parameters a=102.77, b=185.92, c=102.97 A. These particular unit-cell parameters allowed pseudo-merohedral twinning; interestingly, the twinning law relates a twofold screw axis to a twofold axis.


===UNUSUAL TWINNING IN CRYSTALS OF THE CITS BINDING ANTIBODY FAB FRAGMENT F3P4===
Structure of the recombinant antibody Fab fragment f3p4.,Frey D, Huber T, Pluckthun A, Grutter MG Acta Crystallogr D Biol Crystallogr. 2008 Jun;64(Pt 6):636-43. Epub 2008 May 14. PMID:18560151<ref>PMID:18560151</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
==About this Structure==
</div>
2V7N is a 8 chains structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V7N OCA].
<div class="pdbe-citations 2v7n" style="background-color:#fffaf0;"></div>
[[Category: Frey, D.]]
== References ==
[[Category: Gruetter, M G.]]
<references/>
[[Category: Huber, T.]]
__TOC__
[[Category: Plueckthun, A.]]
</StructureSection>
[[Category: Binding protein]]
[[Category: Large Structures]]
[[Category: Immune system]]
[[Category: Synthetic construct]]
[[Category: Phage display]]
[[Category: Frey D]]
[[Category: Recombinant fab fragment]]
[[Category: Gruetter MG]]
 
[[Category: Huber T]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 11:04:06 2009''
[[Category: Plueckthun A]]
Retrieved from "https://proteopedia.org/2v7n"