2cz6: Difference between revisions

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New page: left|200px<br /><applet load="2cz6" size="450" color="white" frame="true" align="right" spinBox="true" caption="2cz6, resolution 1.50Å" /> '''Complex of Inactive ...
 
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[[Image:2cz6.gif|left|200px]]<br /><applet load="2cz6" size="450" color="white" frame="true" align="right" spinBox="true"
caption="2cz6, resolution 1.50&Aring;" />
'''Complex of Inactive Fe-type NHase with Cyclohexyl isocyanide'''<br />


==About this Structure==
==Complex of Inactive Fe-type NHase with Cyclohexyl isocyanide==
2CZ6 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Rhodococcus_erythropolis Rhodococcus erythropolis] with FE, MG, NO and CYI as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Nitrile_hydratase Nitrile hydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.84 4.2.1.84] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2CZ6 OCA].  
<StructureSection load='2cz6' size='340' side='right'caption='[[2cz6]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
[[Category: Nitrile hydratase]]
== Structural highlights ==
[[Category: Protein complex]]
<table><tr><td colspan='2'>[[2cz6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rhodococcus_erythropolis Rhodococcus erythropolis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CZ6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CZ6 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene>, <scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=CYI:CYCLOHEXYL+ISOCYANIDE'>CYI</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NO:NITRIC+OXIDE'>NO</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cz6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cz6 OCA], [https://pdbe.org/2cz6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cz6 RCSB], [https://www.ebi.ac.uk/pdbsum/2cz6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cz6 ProSAT], [https://www.topsan.org/Proteins/RSGI/2cz6 TOPSAN]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NHAA_RHOER NHAA_RHOER] NHase catalyzes the hydration of various nitrile compounds to the corresponding amides. Industrial production of acrylamide is now being developed using some of the enzymes of this class.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cz/2cz6_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cz6 ConSurf].
<div style="clear:both"></div>
 
==See Also==
*[[Nitrile hydratase|Nitrile hydratase]]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Rhodococcus erythropolis]]
[[Category: Rhodococcus erythropolis]]
[[Category: Hashimoto, K.]]
[[Category: Hashimoto K]]
[[Category: Kamiya, N.]]
[[Category: Kamiya N]]
[[Category: Kawano, Y.]]
[[Category: Kawano Y]]
[[Category: Nojiri, M.]]
[[Category: Nojiri M]]
[[Category: RSGI, RIKEN.Structural.Genomics/Proteomics.Initiative.]]
[[Category: CYI]]
[[Category: FE]]
[[Category: MG]]
[[Category: NO]]
[[Category: complex]]
[[Category: cysteine-sulfenic acid]]
[[Category: cysteine-sulfinic acid]]
[[Category: hydration]]
[[Category: national project on protein structural and functional analyses]]
[[Category: nitrile]]
[[Category: nppsfa]]
[[Category: photo-reactive]]
[[Category: riken structural genomics/proteomics initiative]]
[[Category: rsgi]]
[[Category: structural genomics]]
[[Category: substrate analogue]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 09:21:31 2007''
Retrieved from "https://proteopedia.org/2cz6"