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New page: left|200px<br /><applet load="2czf" size="450" color="white" frame="true" align="right" spinBox="true" caption="2czf, resolution 1.85Å" /> '''Crystal structure of...
 
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[[Image:2czf.gif|left|200px]]<br /><applet load="2czf" size="450" color="white" frame="true" align="right" spinBox="true"
caption="2czf, resolution 1.85&Aring;" />
'''Crystal structure of orotidine 5'-phosphate decarboxylase from Pyrococcus horikoshii OT3 complexed with XMP'''<br />


==About this Structure==
==Crystal structure of orotidine 5'-phosphate decarboxylase from Pyrococcus horikoshii OT3 complexed with XMP==
2CZF is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Pyrococcus_horikoshii Pyrococcus horikoshii] with XMP as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Orotidine-5'-phosphate_decarboxylase Orotidine-5'-phosphate decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.23 4.1.1.23] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2CZF OCA].
<StructureSection load='2czf' size='340' side='right'caption='[[2czf]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
[[Category: Orotidine-5'-phosphate decarboxylase]]
== Structural highlights ==
[[Category: Pyrococcus horikoshii]]
<table><tr><td colspan='2'>[[2czf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_horikoshii_OT3 Pyrococcus horikoshii OT3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CZF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CZF FirstGlance]. <br>
[[Category: Single protein]]
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
[[Category: Arai, R.]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=XMP:XANTHOSINE-5-MONOPHOSPHATE'>XMP</scene></td></tr>
[[Category: Ito, K.]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2czf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2czf OCA], [https://pdbe.org/2czf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2czf RCSB], [https://www.ebi.ac.uk/pdbsum/2czf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2czf ProSAT], [https://www.topsan.org/Proteins/RSGI/2czf TOPSAN]</span></td></tr>
[[Category: RSGI, RIKEN.Structural.Genomics/Proteomics.Initiative.]]
</table>
[[Category: Shirouzu, M.]]
== Function ==
[[Category: Yokoyama, S.]]
[https://www.uniprot.org/uniprot/PYRF_PYRHO PYRF_PYRHO] Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity).[HAMAP-Rule:MF_01200_A]
[[Category: XMP]]
== Evolutionary Conservation ==
[[Category: national project on protein structural and functional analyses]]
[[Image:Consurf_key_small.gif|200px|right]]
[[Category: nppsfa]]
Check<jmol>
[[Category: omp decase]]
  <jmolCheckbox>
[[Category: orotidine 5'-phosphate decarboxylase]]
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cz/2czf_consurf.spt"</scriptWhenChecked>
[[Category: pyrimidine biosynthesis]]
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
[[Category: riken structural genomics/proteomics initiative]]
    <text>to colour the structure by Evolutionary Conservation</text>
[[Category: rsgi]]
  </jmolCheckbox>
[[Category: structural genomics]]
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2czf ConSurf].
[[Category: xmp]]
<div style="clear:both"></div>


''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 09:21:53 2007''
==See Also==
*[[Uridine 5'-monophosphate synthase 3D structures|Uridine 5'-monophosphate synthase 3D structures]]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Pyrococcus horikoshii OT3]]
[[Category: Arai R]]
[[Category: Ito K]]
[[Category: Shirouzu M]]
[[Category: Yokoyama S]]

Latest revision as of 13:13, 1 July 2026

Crystal structure of orotidine 5'-phosphate decarboxylase from Pyrococcus horikoshii OT3 complexed with XMP

2czf, resolution 1.85Å

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