2q8g: Difference between revisions

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{{Seed}}
[[Image:2q8g.png|left|200px]]


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==Structure of pyruvate dehydrogenase kinase isoform 1 in complex with glucose-lowering drug AZD7545==
The line below this paragraph, containing "STRUCTURE_2q8g", creates the "Structure Box" on the page.
<StructureSection load='2q8g' size='340' side='right'caption='[[2q8g]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2q8g]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q8G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Q8G FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AZX:4-[(3-CHLORO-4-{[(2R)-3,3,3-TRIFLUORO-2-HYDROXY-2-METHYLPROPANOYL]AMINO}PHENYL)SULFONYL]-N,N-DIMETHYLBENZAMIDE'>AZX</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
{{STRUCTURE_2q8g| PDB=2q8g |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2q8g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q8g OCA], [https://pdbe.org/2q8g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2q8g RCSB], [https://www.ebi.ac.uk/pdbsum/2q8g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2q8g ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PDK1_HUMAN PDK1_HUMAN] Serine/threonine kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia. Protects cells against apoptosis in response to hypoxia and oxidative stress.<ref>PMID:7499431</ref> <ref>PMID:18541534</ref> <ref>PMID:22195962</ref> <ref>PMID:17683942</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q8/2q8g_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2q8g ConSurf].
<div style="clear:both"></div>


===Structure of pyruvate dehydrogenase kinase isoform 1 in complex with glucose-lowering drug AZD7545===
==See Also==
 
*[[Pyruvate dehydrogenase kinase|Pyruvate dehydrogenase kinase]]
 
== References ==
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<references/>
The line below this paragraph, {{ABSTRACT_PUBMED_17683942}}, adds the Publication Abstract to the page
__TOC__
(as it appears on PubMed at http://www.pubmed.gov), where 17683942 is the PubMed ID number.
</StructureSection>
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{{ABSTRACT_PUBMED_17683942}}
 
==About this Structure==
2Q8G is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q8G OCA].
 
==Reference==
<ref group="xtra">PMID:17683942</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Chuang, D T.]]
[[Category: Large Structures]]
[[Category: Chuang, J L.]]
[[Category: Chuang DT]]
[[Category: Kato, M.]]
[[Category: Chuang JL]]
[[Category: Li, J.]]
[[Category: Kato M]]
[[Category: Ghkl atpase/kinase family]]
[[Category: Li J]]
[[Category: Glucose-lowering drug azd7545]]
[[Category: Mitochondrial kinase]]
[[Category: Pyruvate dehydrogenase complex]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 12:31:08 2009''
Retrieved from "https://proteopedia.org/2q8g"