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New page: left|200px<br /><applet load="2dfj" size="450" color="white" frame="true" align="right" spinBox="true" caption="2dfj, resolution 2.72Å" /> '''Crystal Structure of...
 
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[[Image:2dfj.jpg|left|200px]]<br /><applet load="2dfj" size="450" color="white" frame="true" align="right" spinBox="true"
caption="2dfj, resolution 2.72&Aring;" />
'''Crystal Structure of the Diadenosine Tetraphosphate Hydrolase from Shigella flexneri 2a'''<br />


==About this Structure==
==Crystal Structure of the Diadenosine Tetraphosphate Hydrolase from Shigella flexneri 2a==
2DFJ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Shigella_flexneri_2a Shigella flexneri 2a] with MN as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Bis(5'-nucleosyl)-tetraphosphatase_(symmetrical) Bis(5'-nucleosyl)-tetraphosphatase (symmetrical)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.41 3.6.1.41] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2DFJ OCA].  
<StructureSection load='2dfj' size='340' side='right'caption='[[2dfj]], [[Resolution|resolution]] 2.72&Aring;' scene=''>
 
== Structural highlights ==
==Reference==
<table><tr><td colspan='2'>[[2dfj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Shigella_flexneri_2a Shigella flexneri 2a]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DFJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DFJ FirstGlance]. <br>
Crystal structure of the diadenosine tetraphosphate hydrolase from Shigella flexneri 2a., Wang QH, Hu WX, Gao W, Bi RC, Proteins. 2006 Dec 1;65(4):1032-5. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17006950 17006950]
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.72&#8491;</td></tr>
[[Category: Bis(5'-nucleosyl)-tetraphosphatase (symmetrical)]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dfj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dfj OCA], [https://pdbe.org/2dfj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dfj RCSB], [https://www.ebi.ac.uk/pdbsum/2dfj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dfj ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/APAH_SHIFL APAH_SHIFL] Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP.[HAMAP-Rule:MF_00199]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/df/2dfj_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dfj ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Shigella flexneri 2a]]
[[Category: Shigella flexneri 2a]]
[[Category: Single protein]]
[[Category: Bi RC]]
[[Category: Bi, R.C.]]
[[Category: Hu WX]]
[[Category: Hu, W.X.]]
[[Category: Wang QH]]
[[Category: Wang, Q.H.]]
[[Category: MN]]
[[Category: helices and strands mixture]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 09:35:13 2007''
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