1r2b: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,615 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,615 edits
No edit summary
 
(10 intermediate revisions by the same user not shown)
Line 1: Line 1:
{{Seed}}
[[Image:1r2b.png|left|200px]]


<!--
==Crystal structure of the BCL6 BTB domain complexed with a SMRT co-repressor peptide==
The line below this paragraph, containing "STRUCTURE_1r2b", creates the "Structure Box" on the page.
<StructureSection load='1r2b' size='340' side='right'caption='[[1r2b]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1r2b]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R2B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1R2B FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1r2b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r2b OCA], [https://pdbe.org/1r2b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1r2b RCSB], [https://www.ebi.ac.uk/pdbsum/1r2b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1r2b ProSAT]</span></td></tr>
{{STRUCTURE_1r2b| PDB=1r2b |  SCENE= }}
</table>
== Disease ==
[https://www.uniprot.org/uniprot/BCL6_HUMAN BCL6_HUMAN] Note=Chromosomal aberrations involving BCL6 may be a cause of B-cell non-Hodgkin lymphoma. Translocation t(3;14)(q27;q32); translocation t(3;22)(q27;q11) with immunoglobulin gene regions.  Note=A chromosomal aberration involving BCL6 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with POU2AF1/OBF1.  Note=A chromosomal aberration involving BCL6 may be a cause of lymphoma. Translocation t(3;4)(q27;p11) with ARHH/TTF.
== Function ==
[https://www.uniprot.org/uniprot/BCL6_HUMAN BCL6_HUMAN] Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis.<ref>PMID:9649500</ref> <ref>PMID:18280243</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r2/1r2b_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1r2b ConSurf].
<div style="clear:both"></div>


===Crystal structure of the BCL6 BTB domain complexed with a SMRT co-repressor peptide===
==See Also==
 
*[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]]
 
*[[Nuclear receptor corepressor|Nuclear receptor corepressor]]
<!--
== References ==
The line below this paragraph, {{ABSTRACT_PUBMED_14690607}}, adds the Publication Abstract to the page
<references/>
(as it appears on PubMed at http://www.pubmed.gov), where 14690607 is the PubMed ID number.
__TOC__
-->
</StructureSection>
{{ABSTRACT_PUBMED_14690607}}
 
==Disease==
Known disease associated with this structure: Lymphoma, B-cell OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=109565 109565]]
 
==About this Structure==
1R2B is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R2B OCA].
 
==Reference==
<ref group="xtra">PMID:14690607</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Ahmad, K F.]]
[[Category: Large Structures]]
[[Category: Bouchard, D.]]
[[Category: Ahmad KF]]
[[Category: Kiang, C L.]]
[[Category: Bouchard D]]
[[Category: Lax, S A.]]
[[Category: Kiang CL]]
[[Category: Licht, J D.]]
[[Category: Lax SA]]
[[Category: Liu, J.]]
[[Category: Licht JD]]
[[Category: Mayer, S.]]
[[Category: Liu J]]
[[Category: Melnick, A.]]
[[Category: Mayer S]]
[[Category: Prive, G G.]]
[[Category: Melnick A]]
[[Category: B-cell lymphoma]]
[[Category: Prive GG]]
[[Category: Btb domain]]
[[Category: Hdac complex]]
[[Category: Transcriptional repression]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 13:50:39 2009''

Latest revision as of 08:19, 14 February 2024

Crystal structure of the BCL6 BTB domain complexed with a SMRT co-repressor peptide

1r2b, resolution 2.20Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=1r2b&oldid=4054109"