2aie: Difference between revisions

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{{Seed}}
[[Image:2aie.png|left|200px]]


<!--
==S.pneumoniae polypeptide deformylase complexed with SB-505684==
The line below this paragraph, containing "STRUCTURE_2aie", creates the "Structure Box" on the page.
<StructureSection load='2aie' size='340' side='right'caption='[[2aie]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2aie]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AIE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AIE FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=SB9:HYDROXY[3-(6-METHYLPYRIDIN-2-YL)PROPYL]FORMAMIDE'>SB9</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
{{STRUCTURE_2aie|  PDB=2aie  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2aie FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aie OCA], [https://pdbe.org/2aie PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2aie RCSB], [https://www.ebi.ac.uk/pdbsum/2aie PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2aie ProSAT]</span></td></tr>
 
</table>
===S.pneumoniae polypeptide deformylase complexed with SB-505684===
== Function ==
 
[https://www.uniprot.org/uniprot/DEF_STRR6 DEF_STRR6] Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity).
 
== Evolutionary Conservation ==
<!--
[[Image:Consurf_key_small.gif|200px|right]]
The line below this paragraph, {{ABSTRACT_PUBMED_12538898}}, adds the Publication Abstract to the page
Check<jmol>
(as it appears on PubMed at http://www.pubmed.gov), where 12538898 is the PubMed ID number.
  <jmolCheckbox>
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    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ai/2aie_consurf.spt"</scriptWhenChecked>
{{ABSTRACT_PUBMED_12538898}}
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 
    <text>to colour the structure by Evolutionary Conservation</text>
==About this Structure==
  </jmolCheckbox>
2AIE is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AIE OCA].  
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2aie ConSurf].
 
<div style="clear:both"></div>
==Reference==
__TOC__
<ref group="xtra">PMID:12538898</ref><references group="xtra"/>
</StructureSection>
[[Category: Peptide deformylase]]
[[Category: Large Structures]]
[[Category: Streptococcus pneumoniae]]
[[Category: Streptococcus pneumoniae]]
[[Category: Aubart, K.]]
[[Category: Aubart K]]
[[Category: Christensen, S B.]]
[[Category: Christensen SB]]
[[Category: Fosberry, A.]]
[[Category: Fosberry A]]
[[Category: Jones, J.]]
[[Category: Jones J]]
[[Category: Lewis, C.]]
[[Category: Lewis C]]
[[Category: Lonetto, M.]]
[[Category: Lonetto M]]
[[Category: McManus, E.]]
[[Category: McManus E]]
[[Category: Petit, C M.]]
[[Category: Petit CM]]
[[Category: Smith, K J.]]
[[Category: Smith KJ]]
[[Category: Smyth, M.]]
[[Category: Smyth M]]
[[Category: Hydrolase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 14:21:38 2009''
Retrieved from "https://proteopedia.org/2aie"