2exg: Difference between revisions
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==Making Protein-Protein Interactions Drugable: Discovery of Low-Molecular-Weight Ligands for the AF6 PDZ Domain== | |||
<StructureSection load='2exg' size='340' side='right'caption='[[2exg]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2exg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EXG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EXG FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=STF:(5R)-2-SULFANYL-5-[4-(TRIFLUOROMETHYL)BENZYL]-1,3-THIAZOL-4-ONE'>STF</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2exg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2exg OCA], [https://pdbe.org/2exg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2exg RCSB], [https://www.ebi.ac.uk/pdbsum/2exg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2exg ProSAT]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[[https://www.uniprot.org/uniprot/AFAD_HUMAN AFAD_HUMAN]] Note=A chromosomal aberration involving MLLT4 is associated with acute leukemias. Translocation t(6;11)(q27;q23) with MLL/HRX. The result is a rogue activator protein. | |||
== Function == | |||
[[https://www.uniprot.org/uniprot/AFAD_HUMAN AFAD_HUMAN]] Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton. | |||
== | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
== | <jmolCheckbox> | ||
< | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ex/2exg_consurf.spt"</scriptWhenChecked> | ||
[[Category: | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
[[Category: Boisguerin, P | <text>to colour the structure by Evolutionary Conservation</text> | ||
[[Category: Joshi, M | </jmolCheckbox> | ||
[[Category: Krause, G | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2exg ConSurf]. | ||
[[Category: Oschkinat, H | <div style="clear:both"></div> | ||
[[Category: Schade, M | __TOC__ | ||
[[Category: Vargas, C | </StructureSection> | ||
[[Category: Human]] | |||
[[Category: Large Structures]] | |||
[[Category: Boisguerin, P]] | |||
[[Category: Joshi, M]] | |||
[[Category: Krause, G]] | |||
[[Category: Oschkinat, H]] | |||
[[Category: Schade, M]] | |||
[[Category: Vargas, C]] | |||
[[Category: Cell adhesion]] | |||
[[Category: Inhibitors of protein-protein interaction]] | [[Category: Inhibitors of protein-protein interaction]] | ||
[[Category: Low-molecular-weight ligand]] | [[Category: Low-molecular-weight ligand]] | ||
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[[Category: Pdz domain]] | [[Category: Pdz domain]] | ||
[[Category: Protein structure]] | [[Category: Protein structure]] | ||
Latest revision as of 15:58, 22 December 2021
Making Protein-Protein Interactions Drugable: Discovery of Low-Molecular-Weight Ligands for the AF6 PDZ Domain
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