1i85: Difference between revisions

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{{Seed}}
[[Image:1i85.png|left|200px]]


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==CRYSTAL STRUCTURE OF THE CTLA-4/B7-2 COMPLEX==
The line below this paragraph, containing "STRUCTURE_1i85", creates the "Structure Box" on the page.
<StructureSection load='1i85' size='340' side='right'caption='[[1i85]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1i85]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I85 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1I85 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1i85 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i85 OCA], [https://pdbe.org/1i85 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1i85 RCSB], [https://www.ebi.ac.uk/pdbsum/1i85 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1i85 ProSAT]</span></td></tr>
{{STRUCTURE_1i85| PDB=1i85 |  SCENE= }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/CD86_HUMAN CD86_HUMAN] Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i8/1i85_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1i85 ConSurf].
<div style="clear:both"></div>


===CRYSTAL STRUCTURE OF THE CTLA-4/B7-2 COMPLEX===
==See Also==
 
*[[CTLA-4|CTLA-4]]
 
__TOC__
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</StructureSection>
The line below this paragraph, {{ABSTRACT_PUBMED_11279501}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 11279501 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_11279501}}
 
==Disease==
Known disease associated with this structure: Celiac disease, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=123890 123890]], Diabetes mellitus, insulin-dependent, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=123890 123890]], Graves disease, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=123890 123890]], Hypothyroidism, autoimmune OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=123890 123890]]
 
==About this Structure==
1I85 is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I85 OCA].
 
==Reference==
<ref group="xtra">PMID:11279501</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Almo, S C.]]
[[Category: Large Structures]]
[[Category: Fedorov, A A.]]
[[Category: Almo SC]]
[[Category: Nathenson, S G.]]
[[Category: Fedorov AA]]
[[Category: Schwartz, J C.D.]]
[[Category: Nathenson SG]]
[[Category: Zhang, X.]]
[[Category: Schwartz J-CD]]
[[Category: Ig v-type domain]]
[[Category: Zhang X]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 14:29:20 2009''
Retrieved from "https://proteopedia.org/1i85"