2dxa: Difference between revisions

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New page: left|200px<br /><applet load="2dxa" size="450" color="white" frame="true" align="right" spinBox="true" caption="2dxa, resolution 1.58Å" /> '''Crystal structure of...
 
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[[Image:2dxa.jpg|left|200px]]<br /><applet load="2dxa" size="450" color="white" frame="true" align="right" spinBox="true"
caption="2dxa, resolution 1.58&Aring;" />
'''Crystal structure of trans editing enzyme ProX from E.coli'''<br />


==About this Structure==
==Crystal structure of trans editing enzyme ProX from E.coli==
2DXA is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with CL as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2DXA OCA].  
<StructureSection load='2dxa' size='340' side='right'caption='[[2dxa]], [[Resolution|resolution]] 1.58&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2dxa]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DXA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DXA FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.58&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dxa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dxa OCA], [https://pdbe.org/2dxa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dxa RCSB], [https://www.ebi.ac.uk/pdbsum/2dxa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dxa ProSAT], [https://www.topsan.org/Proteins/RSGI/2dxa TOPSAN]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/YBAK_ECOLI YBAK_ECOLI] Functions in trans to edit the amino acid from incorrectly charged Cys-tRNA(Pro) via a Cys-tRNA(Pro) deacylase activity. May compensate for the lack of Cys-tRNA(Pro) editing by ProRS. Is also able to deacylate Cys-tRNA(Cys), and displays weak deacylase activity in vitro against Gly-tRNA(Gly), as well as, at higher concentrations, some other correctly charged tRNAs. Unlike some of its orthologs it is not able to remove the amino acid moiety from incorrectly charged Ala-tRNA(Pro).<ref>PMID:15886196</ref> <ref>PMID:23185990</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dx/2dxa_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dxa ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Kato-Murayama, M.]]
[[Category: Kato-Murayama M]]
[[Category: Murayama, K.]]
[[Category: Murayama K]]
[[Category: RSGI, RIKEN.Structural.Genomics/Proteomics.Initiative.]]
[[Category: Shirouzu M]]
[[Category: Shirouzu, M.]]
[[Category: Terada T]]
[[Category: Terada, T.]]
[[Category: Yokoyama S]]
[[Category: Yokoyama, S.]]
[[Category: CL]]
[[Category: national project on protein structural and functional analyses]]
[[Category: nppsfa]]
[[Category: prolyl-trna synthetase]]
[[Category: riken structural genomics/proteomics initiative]]
[[Category: rsgi]]
[[Category: structural genomics]]
[[Category: trans-editing domain]]
 
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Retrieved from "https://proteopedia.org/2dxa"