1p6t: Difference between revisions

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{{Seed}}
[[Image:1p6t.png|left|200px]]


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==Structure characterization of the water soluble region of P-type ATPase CopA from Bacillus subtilis==
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<StructureSection load='1p6t' size='340' side='right'caption='[[1p6t]]' scene=''>
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== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1p6t]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P6T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1P6T FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1p6t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p6t OCA], [https://pdbe.org/1p6t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1p6t RCSB], [https://www.ebi.ac.uk/pdbsum/1p6t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1p6t ProSAT]</span></td></tr>
{{STRUCTURE_1p6t|  PDB=1p6t  |  SCENE=  }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/COPA_BACSU COPA_BACSU] Involved in copper export.<ref>PMID:12644235</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p6/1p6t_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1p6t ConSurf].
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== Publication Abstract from PubMed ==
The solution structure of the N-terminal region (151 amino acids) of a copper ATPase, CopA, from Bacillus subtilis, is reported here. It consists of two domains, CopAa and CopAb, linked by two amino acids. It is found that the two domains, which had already been separately characterized, interact one to the other through a hydrogen bond network and a few hydrophobic interactions, forming a single rigid body. The two metal binding sites are far from one another, and the short link between the domains prevents them from interacting. This and the surface electrostatic potential suggest that each domain receives copper from the copper chaperone, CopZ, independently and transfers it to the membrane binding site of CopA. The affinity constants of silver(I) and copper(I) are similar for the two sites as monitored by NMR. Because the present construct "domain-short link-domain" is shared also by the last two domains of the eukaryotic copper ATPases and several residues at the interface between the two domains are conserved, the conclusions of the present study have general validity for the understanding of the function of copper ATPases.


===Structure characterization of the water soluble region of P-type ATPase CopA from Bacillus subtilis===
Structural basis for the function of the N-terminal domain of the ATPase CopA from Bacillus subtilis.,Banci L, Bertini I, Ciofi-Baffoni S, Gonnelli L, Su XC J Biol Chem. 2003 Dec 12;278(50):50506-13. Epub 2003 Sep 27. PMID:14514665<ref>PMID:14514665</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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(as it appears on PubMed at http://www.pubmed.gov), where 14514665 is the PubMed ID number.
== References ==
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<references/>
{{ABSTRACT_PUBMED_14514665}}
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</StructureSection>
==About this Structure==
1P6T is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P6T OCA].
 
==Reference==
<ref group="xtra">PMID:14514665</ref><references group="xtra"/>
[[Category: Bacillus subtilis]]
[[Category: Bacillus subtilis]]
[[Category: Copper-exporting ATPase]]
[[Category: Large Structures]]
[[Category: Banci, L.]]
[[Category: Banci L]]
[[Category: Bertini, I.]]
[[Category: Bertini I]]
[[Category: Ciofi-Baffoni, S.]]
[[Category: Ciofi-Baffoni S]]
[[Category: Gonnelli, L.]]
[[Category: Gonnelli L]]
[[Category: SPINE, Structural Proteomics in Europe.]]
[[Category: Su XC]]
[[Category: Su, X C.]]
[[Category: Beta-alpha-beta-beta-alpha-beta fold]]
[[Category: Copa]]
[[Category: Nmr]]
[[Category: P-type atpase]]
[[Category: Spine]]
[[Category: Structural genomic]]
[[Category: Structural proteomics in europe]]
[[Category: Water-soluble region]]
 
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Retrieved from "https://proteopedia.org/1p6t"