3c3w: Difference between revisions

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{{Seed}}
[[Image:3c3w.png|left|200px]]


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==Crystal Structure of the Mycobacterium tuberculosis Hypoxic Response Regulator DosR==
The line below this paragraph, containing "STRUCTURE_3c3w", creates the "Structure Box" on the page.
<StructureSection load='3c3w' size='340' side='right'caption='[[3c3w]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3c3w]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C3W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3C3W FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
{{STRUCTURE_3c3w| PDB=3c3w |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3c3w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c3w OCA], [https://pdbe.org/3c3w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3c3w RCSB], [https://www.ebi.ac.uk/pdbsum/3c3w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3c3w ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DEVR_MYCTU DEVR_MYCTU] Member of the two-component regulatory system DevR/DevS (also called DosR/DosS) involved in onset of the dormancy response (PubMed:15033981). Regulates an approximately 48-member regulon (PubMed:12953092, PubMed:11416222, PubMed:15033981, PubMed:18400743). When phosphorylated binds and activates the promoter of DevR regulon genes in response to hypoxia (PubMed:18359816, PubMed:21764934, PubMed:28977726). The presence of target DNA increases stability of phospho-DevR in vitro (PubMed:28977726). Activates its own transcription under hypoxic but not aerobic conditions, probably binds as a dimer to tandem binding sites within the devR and hspX promoters (PubMed:18359816). Accepts a phosphate group from DevS (DosS) and from DosT (PubMed:15033981, PubMed:15073296, PubMed:21764934, PubMed:28977726). Does not regulate transcription of dosT (PubMed:19487478).<ref>PMID:11416222</ref> <ref>PMID:12953092</ref> <ref>PMID:15033981</ref> <ref>PMID:15073296</ref> <ref>PMID:18359816</ref> <ref>PMID:18400743</ref> <ref>PMID:19487478</ref> <ref>PMID:21764934</ref> <ref>PMID:28977726</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c3/3c3w_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3c3w ConSurf].
<div style="clear:both"></div>


===Crystal Structure of the Mycobacterium tuberculosis Hypoxic Response Regulator DosR===
==See Also==
 
*[[Response regulator 3D structure|Response regulator 3D structure]]
 
== References ==
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<references/>
The line below this paragraph, {{ABSTRACT_PUBMED_18353359}}, adds the Publication Abstract to the page
__TOC__
(as it appears on PubMed at http://www.pubmed.gov), where 18353359 is the PubMed ID number.
</StructureSection>
-->
[[Category: Large Structures]]
{{ABSTRACT_PUBMED_18353359}}
 
==About this Structure==
3C3W is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C3W OCA].
 
==Reference==
<ref group="xtra">PMID:18353359</ref><references group="xtra"/>
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Hol, W G.J.]]
[[Category: Hol WGJ]]
[[Category: Sherman, D R.]]
[[Category: Sherman DR]]
[[Category: Wisedchaisri, G.]]
[[Category: Wisedchaisri G]]
[[Category: Wu, M.]]
[[Category: Wu M]]
[[Category: Dna-binding protein]]
[[Category: Response regulator]]
[[Category: Transcription]]
[[Category: Transcription regulation]]
[[Category: Tuberculosis]]
[[Category: Two-component regulatory system]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 16:57:01 2009''
Retrieved from "https://proteopedia.org/3c3w"