1lww: Difference between revisions

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{{Seed}}
[[Image:1lww.png|left|200px]]


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==Borohydride-trapped hOgg1 Intermediate Structure Co-Crystallized with 8-bromoguanine==
The line below this paragraph, containing "STRUCTURE_1lww", creates the "Structure Box" on the page.
<StructureSection load='1lww' size='340' side='right'caption='[[1lww]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1lww]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LWW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LWW FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BRG:8-BROMOGUANINE'>BRG</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PED:PENTANE-3,4-DIOL-5-PHOSPHATE'>PED</scene></td></tr>
{{STRUCTURE_1lww|  PDB=1lww  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lww FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lww OCA], [https://pdbe.org/1lww PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lww RCSB], [https://www.ebi.ac.uk/pdbsum/1lww PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lww ProSAT]</span></td></tr>
</table>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lw/1lww_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lww ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Most spontaneous damage to bases in DNA is corrected through the action of the base-excision DNA repair pathway. Base excision repair is initiated by DNA glycosylases, lesion-specific enzymes that intercept aberrant bases in DNA and catalyze their excision. How such proteins accomplish the feat of catalyzing no fewer than five sequential reaction steps using a single active site has been unknown. To help answer this, we report the structure of a trapped catalytic intermediate in DNA repair by human 8-oxoguanine DNA glycosylase. This structure and supporting biochemical results reveal that the enzyme sequesters the excised lesion base and exploits it as a cofactor to participate in catalysis. To our knowledge, the present example represents the first documented case of product-assisted catalysis in an enzyme-catalyzed reaction.


===Borohydride-trapped hOgg1 Intermediate Structure Co-Crystallized with 8-bromoguanine===
Product-assisted catalysis in base-excision DNA repair.,Fromme JC, Bruner SD, Yang W, Karplus M, Verdine GL Nat Struct Biol. 2003 Mar;10(3):204-11. PMID:12592398<ref>PMID:12592398</ref>


From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1lww" style="background-color:#fffaf0;"></div>


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==See Also==
The line below this paragraph, {{ABSTRACT_PUBMED_12592398}}, adds the Publication Abstract to the page
*[[DNA glycosylase 3D structures|DNA glycosylase 3D structures]]
(as it appears on PubMed at http://www.pubmed.gov), where 12592398 is the PubMed ID number.
== References ==
-->
<references/>
{{ABSTRACT_PUBMED_12592398}}
__TOC__
 
</StructureSection>
==About this Structure==
1LWW is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LWW OCA].
 
==Reference==
<ref group="xtra">PMID:12592398</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Bruner, S D.]]
[[Category: Large Structures]]
[[Category: Fromme, J C.]]
[[Category: Bruner SD]]
[[Category: Karplus, M.]]
[[Category: Fromme JC]]
[[Category: Verdine, G L.]]
[[Category: Karplus M]]
[[Category: Yang, W.]]
[[Category: Verdine GL]]
[[Category: Borohydride]]
[[Category: Yang W]]
[[Category: Covalent trapping]]
[[Category: Dna glycosylase]]
[[Category: Dna repair]]
[[Category: Product-assisted catalysis]]
[[Category: Protein/dna]]
[[Category: Reaction intermediate]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 17:15:48 2009''

Latest revision as of 00:13, 21 November 2024

Borohydride-trapped hOgg1 Intermediate Structure Co-Crystallized with 8-bromoguanine

1lww, resolution 2.10Å

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