1k2w: Difference between revisions

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{{Seed}}
[[Image:1k2w.png|left|200px]]


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==Crystal structure of sorbitol dehydrogenase from R. sphaeroides==
The line below this paragraph, containing "STRUCTURE_1k2w", creates the "Structure Box" on the page.
<StructureSection load='1k2w' size='340' side='right'caption='[[1k2w]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1k2w]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Cereibacter_sphaeroides Cereibacter sphaeroides]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K2W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1K2W FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1k2w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k2w OCA], [https://pdbe.org/1k2w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1k2w RCSB], [https://www.ebi.ac.uk/pdbsum/1k2w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1k2w ProSAT]</span></td></tr>
{{STRUCTURE_1k2w|  PDB=1k2w  |  SCENE=  }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/SDH_CERSP SDH_CERSP] Catalyzes the oxidation of D-sorbitol (D-glucitol) to D-fructose. Can also catalyze the oxidation of galactitol to D-tagatose and the oxidation of L-iditol, with lower efficiency.<ref>PMID:7551049</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k2/1k2w_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1k2w ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Recombinant sorbitol dehydrogenase (SDH) from Rhodobacter sphaeroides has been crystallized in the absence of the cofactor NAD(H) and its structure determined to 2.4 A resolution using molecular replacement (refined R and R free factors of 18.8 and 23.8%, respectively). As expected from the sequence and shown by the conserved fold, SDH can be assigned to the short-chain dehydrogenase/reductase protein family. The cofactor NAD and the substrate sorbitol have been modelled into the structure and the active-site architecture, which displays the highly conserved catalytic tetrad of Asn-Ser-Tyr-Lys residues, is discussed in relation to the enzyme mechanism. This is the first structure of a bacterial SDH belonging to the SDR family.


===Crystal structure of sorbitol dehydrogenase from R. sphaeroides===
Structure of zinc-independent sorbitol dehydrogenase from Rhodobacter sphaeroides at 2.4 A resolution.,Philippsen A, Schirmer T, Stein MA, Giffhorn F, Stetefeld J Acta Crystallogr D Biol Crystallogr. 2005 Apr;61(Pt 4):374-9. Epub 2005, Mar 24. PMID:15805591<ref>PMID:15805591</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 1k2w" style="background-color:#fffaf0;"></div>
(as it appears on PubMed at http://www.pubmed.gov), where 15805591 is the PubMed ID number.
== References ==
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<references/>
{{ABSTRACT_PUBMED_15805591}}
__TOC__
 
</StructureSection>
==About this Structure==
[[Category: Cereibacter sphaeroides]]
1K2W is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Rhodobacter_sphaeroides Rhodobacter sphaeroides]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K2W OCA].
[[Category: Large Structures]]
 
[[Category: Philippsen A]]
==Reference==
[[Category: Schirmer T]]
<ref group="xtra">PMID:15805591</ref><references group="xtra"/>
[[Category: Stetefeld J]]
[[Category: L-iditol 2-dehydrogenase]]
[[Category: Rhodobacter sphaeroides]]
[[Category: Philippsen, A.]]
[[Category: Schirmer, T.]]
[[Category: Stetefeld, J.]]
[[Category: Enzyme]]
[[Category: Short-chain dehydrogenase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 17:40:08 2009''

Latest revision as of 08:49, 16 August 2023

Crystal structure of sorbitol dehydrogenase from R. sphaeroides

1k2w, resolution 2.40Å

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