1ktx: Difference between revisions

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{{Seed}}
[[Image:1ktx.png|left|200px]]


<!--
==KALIOTOXIN (1-37) SHOWS STRUCTURAL DIFFERENCES WITH RELATED POTASSIUM CHANNEL BLOCKERS==
The line below this paragraph, containing "STRUCTURE_1ktx", creates the "Structure Box" on the page.
<StructureSection load='1ktx' size='340' side='right'caption='[[1ktx]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1ktx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Androctonus_mauritanicus_mauritanicus Androctonus mauritanicus mauritanicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KTX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KTX FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
{{STRUCTURE_1ktx| PDB=1ktx |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ktx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ktx OCA], [https://pdbe.org/1ktx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ktx RCSB], [https://www.ebi.ac.uk/pdbsum/1ktx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ktx ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/KAX31_ANDMA KAX31_ANDMA] Potent inhibitor of large conductance calcium-activated potassium channels (BK-Ca). Also binds to the dendrotoxin sensitive voltage-dependent potassium channel. It appears to block channel activity by a simple bimolecular inhibition process. Induces a transient period of fast flickering in the channel openings, followed by an almost complete blockade of the channel. Its binding affinity to rat brain synaptosomes is 5-fold higher than this of KTX-3. Binding of the toxin to the channel is associated with significant structural rearrangements in both molecules.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kt/1ktx_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ktx ConSurf].
<div style="clear:both"></div>


===KALIOTOXIN (1-37) SHOWS STRUCTURAL DIFFERENCES WITH RELATED POTASSIUM CHANNEL BLOCKERS===
==See Also==
 
*[[Potassium channel toxin 3D structures|Potassium channel toxin 3D structures]]
 
__TOC__
<!--
</StructureSection>
The line below this paragraph, {{ABSTRACT_PUBMED_7524673}}, adds the Publication Abstract to the page
[[Category: Androctonus mauritanicus mauritanicus]]
(as it appears on PubMed at http://www.pubmed.gov), where 7524673 is the PubMed ID number.
[[Category: Large Structures]]
-->
[[Category: Fernandez I]]
{{ABSTRACT_PUBMED_7524673}}
[[Category: Giralt E]]
 
[[Category: Martin-Eauclaire M-F]]
==About this Structure==
[[Category: Pons M]]
1KTX is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Androctonus_mauretanicus_mauretanicus Androctonus mauretanicus mauretanicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KTX OCA].
[[Category: Rochat H]]
 
[[Category: Romi R]]
==Reference==
[[Category: Szendefi S]]
<ref group="xtra">PMID:7524673</ref><references group="xtra"/>
[[Category: Van Rietschtoten J]]
[[Category: Androctonus mauretanicus mauretanicus]]
[[Category: Fernandez, I.]]
[[Category: Giralt, E.]]
[[Category: Martin-Eauclaire, M F.]]
[[Category: Pons, M.]]
[[Category: Rietschtoten, J Van.]]
[[Category: Rochat, H.]]
[[Category: Romi, R.]]
[[Category: Szendefi, S.]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 17:40:28 2009''

Latest revision as of 08:03, 3 April 2024

KALIOTOXIN (1-37) SHOWS STRUCTURAL DIFFERENCES WITH RELATED POTASSIUM CHANNEL BLOCKERS

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