1n3j: Difference between revisions

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{{Seed}}
[[Image:1n3j.png|left|200px]]


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==Structure and Substrate of a Histone H3 Lysine Methyltransferase from Paramecium Bursaria Chlorella Virus 1==
The line below this paragraph, containing "STRUCTURE_1n3j", creates the "Structure Box" on the page.
<StructureSection load='1n3j' size='340' side='right'caption='[[1n3j]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1n3j]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Paramecium_bursaria_Chlorella_virus_1 Paramecium bursaria Chlorella virus 1]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N3J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1N3J FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1n3j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n3j OCA], [https://pdbe.org/1n3j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1n3j RCSB], [https://www.ebi.ac.uk/pdbsum/1n3j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1n3j ProSAT]</span></td></tr>
{{STRUCTURE_1n3j|  PDB=1n3j  |  SCENE=  }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/O41094_PBCV1 O41094_PBCV1]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n3/1n3j_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1n3j ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Site-specific lysine methylation of histones by SET domains is a hallmark for epigenetic control of gene transcription in eukaryotic organisms. Here we report that a SET domain protein from Paramecium bursaria chlorella virus can specifically di-methylate Lys27 in histone H3, a modification implicated in gene silencing. The solution structure of the viral SET domain reveals a butterfly-shaped head-to-head symmetric dimer different from other known protein methyltransferases. Each subunit consists of a Greek-key antiparallel beta-barrel and a three-stranded open-faced sandwich that mediates the dimer interface. Cofactor S-adenosyl-L-methionine (SAM) binds at the opening of the beta-barrel, and amino acids C-terminal to Lys27 in H3 and in the flexible C-terminal tail of the enzyme confer the specificity of this viral histone methyltransferase.


===Structure and Substrate of a Histone H3 Lysine Methyltransferase from Paramecium Bursaria Chlorella Virus 1===
A dimeric viral SET domain methyltransferase specific to Lys27 of histone H3.,Manzur KL, Farooq A, Zeng L, Plotnikova O, Koch AW, Sachchidanand, Zhou MM Nat Struct Biol. 2003 Mar;10(3):187-96. PMID:12567185<ref>PMID:12567185</ref>


From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1n3j" style="background-color:#fffaf0;"></div>


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==See Also==
The line below this paragraph, {{ABSTRACT_PUBMED_12567185}}, adds the Publication Abstract to the page
*[[Histone methyltransferase 3D structures|Histone methyltransferase 3D structures]]
(as it appears on PubMed at http://www.pubmed.gov), where 12567185 is the PubMed ID number.
== References ==
-->
<references/>
{{ABSTRACT_PUBMED_12567185}}
__TOC__
 
</StructureSection>
==About this Structure==
[[Category: Large Structures]]
1N3J is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Paramecium_bursaria_chlorella_virus_1 Paramecium bursaria chlorella virus 1]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N3J OCA].
[[Category: Paramecium bursaria Chlorella virus 1]]
 
[[Category: Farooq A]]
==Reference==
[[Category: Koch AW]]
<ref group="xtra">PMID:12567185</ref><references group="xtra"/>
[[Category: Manzur KL]]
[[Category: Paramecium bursaria chlorella virus 1]]
[[Category: Plotnikova O]]
[[Category: Farooq, A.]]
[[Category: Koch, A W.]]
[[Category: Manzur, K L.]]
[[Category: Plotnikova, O.]]
[[Category: Sachchidanand]]
[[Category: Sachchidanand]]
[[Category: Zeng, L.]]
[[Category: Zeng L]]
[[Category: Zhou, M M.]]
[[Category: Zhou M-M]]
[[Category: Beta barrel]]
[[Category: Homodimer]]
 
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Retrieved from "https://proteopedia.org/1n3j"