2j7i: Difference between revisions

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{{Seed}}
[[Image:2j7i.png|left|200px]]


<!--
==ATYPICAL POLYPROLINE RECOGNITION BY THE CMS N-TERMINAL SH3 DOMAIN. CMS:CD2 HETERODIMER==
The line below this paragraph, containing "STRUCTURE_2j7i", creates the "Structure Box" on the page.
<StructureSection load='2j7i' size='340' side='right'caption='[[2j7i]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2j7i]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J7I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2J7I FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2j7i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j7i OCA], [https://pdbe.org/2j7i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2j7i RCSB], [https://www.ebi.ac.uk/pdbsum/2j7i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2j7i ProSAT]</span></td></tr>
{{STRUCTURE_2j7i| PDB=2j7i |  SCENE= }}
</table>
== Disease ==
[https://www.uniprot.org/uniprot/CD2AP_HUMAN CD2AP_HUMAN] Defects in CD2AP are the cause of susceptibility to focal segmental glomerulosclerosis type 3 (FSGS3) [MIM:[https://omim.org/entry/607832 607832]. A renal pathology defined by the presence of segmental sclerosis in glomeruli and resulting in proteinuria, reduced glomerular filtration rate and edema. Renal insufficiency often progresses to end-stage renal disease, a highly morbid state requiring either dialysis therapy or kidney transplantation.<ref>PMID:12764198</ref>
== Function ==
[https://www.uniprot.org/uniprot/CD2AP_HUMAN CD2AP_HUMAN] Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton. May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell. May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis.<ref>PMID:15800069</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j7/2j7i_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2j7i ConSurf].
<div style="clear:both"></div>


===ATYPICAL POLYPROLINE RECOGNITION BY THE CMS N-TERMINAL SH3 DOMAIN. CMS:CD2 HETERODIMER===
==See Also==
 
*[[CD2-associated protein 3D structures|CD2-associated protein 3D structures]]
 
== References ==
<!--
<references/>
The line below this paragraph, {{ABSTRACT_PUBMED_17020880}}, adds the Publication Abstract to the page
__TOC__
(as it appears on PubMed at http://www.pubmed.gov), where 17020880 is the PubMed ID number.
</StructureSection>
-->
{{ABSTRACT_PUBMED_17020880}}
 
==About this Structure==
2J7I is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J7I OCA].
 
==Reference==
<ref group="xtra">PMID:17020880</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Bravo, J.]]
[[Category: Large Structures]]
[[Category: Cardenes, N.]]
[[Category: Bravo J]]
[[Category: Deribe, Y L.]]
[[Category: Cardenes N]]
[[Category: Dikic, I.]]
[[Category: Deribe YL]]
[[Category: Moncalian, G.]]
[[Category: Dikic I]]
[[Category: Spinola-Amilibia, M.]]
[[Category: Moncalian G]]
[[Category: Adaptor protein]]
[[Category: Spinola-Amilibia M]]
[[Category: Cd2ad]]
[[Category: Cell adhesion]]
[[Category: Cm]]
[[Category: Coiled coil]]
[[Category: Egfr downregulation]]
[[Category: Glycoprotein]]
[[Category: Immunoglobulin domain]]
[[Category: Membrane]]
[[Category: Phosphorylation]]
[[Category: Polymorphism]]
[[Category: Protein binding]]
[[Category: Sh3 domain]]
[[Category: Sh3 domain recognition]]
[[Category: Sh3-binding]]
[[Category: Transmembrane]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 18:31:56 2009''
Retrieved from "https://proteopedia.org/2j7i"