2fq9: Difference between revisions

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New page: left|200px<br /><applet load="2fq9" size="450" color="white" frame="true" align="right" spinBox="true" caption="2fq9, resolution 1.650Å" /> '''Cathepsin S with ni...
 
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[[Image:2fq9.gif|left|200px]]<br /><applet load="2fq9" size="450" color="white" frame="true" align="right" spinBox="true"
caption="2fq9, resolution 1.650&Aring;" />
'''Cathepsin S with nitrile inhibitor'''<br />


==About this Structure==
==Cathepsin S with nitrile inhibitor==
2FQ9 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with CRJ as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Cathepsin_S Cathepsin S], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.27 3.4.22.27] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2FQ9 OCA].  
<StructureSection load='2fq9' size='340' side='right'caption='[[2fq9]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
[[Category: Cathepsin S]]
== Structural highlights ==
<table><tr><td colspan='2'>[[2fq9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FQ9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FQ9 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CRJ:N-(1-CYANOCYCLOPROPYL)-3-({[(2S)-5-OXOPYRROLIDIN-2-YL]METHYL}SULFONYL)-N~2~-[(1S)-2,2,2-TRIFLUORO-1-(4-FLUOROPHENYL)ETHYL]-L-ALANINAMIDE'>CRJ</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fq9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fq9 OCA], [https://pdbe.org/2fq9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fq9 RCSB], [https://www.ebi.ac.uk/pdbsum/2fq9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fq9 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CATS_HUMAN CATS_HUMAN] Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fq/2fq9_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fq9 ConSurf].
<div style="clear:both"></div>
 
==See Also==
*[[Cathepsin 3D structures|Cathepsin 3D structures]]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Somoza, J.R.]]
[[Category: Somoza JR]]
[[Category: CRJ]]
[[Category: antigen presentation]]
[[Category: cysteine protease]]
[[Category: drug design]]
[[Category: papain]]
 
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Retrieved from "https://proteopedia.org/2fq9"