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New page: left|200px<br /><applet load="2fxa" size="450" color="white" frame="true" align="right" spinBox="true" caption="2fxa, resolution 2.40Å" /> '''Structure of the Pro...
 
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[[Image:2fxa.gif|left|200px]]<br /><applet load="2fxa" size="450" color="white" frame="true" align="right" spinBox="true"
caption="2fxa, resolution 2.40&Aring;" />
'''Structure of the Protease Production Regulatory Protein hpr from Bacillus subtilis.'''<br />


==About this Structure==
==Structure of the Protease Production Regulatory Protein hpr from Bacillus subtilis.==
2FXA is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis] with EDO, PGE, P6G and 1PE as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2FXA OCA].  
<StructureSection load='2fxa' size='340' side='right'caption='[[2fxa]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2fxa]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FXA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FXA FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fxa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fxa OCA], [https://pdbe.org/2fxa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fxa RCSB], [https://www.ebi.ac.uk/pdbsum/2fxa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fxa ProSAT], [https://www.topsan.org/Proteins/MCSG/2fxa TOPSAN]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HPR_BACSU HPR_BACSU] Negative regulator of protease production and sporulation. Acts by binding directly to the promoter of protease genes (aprE and nprE), and by repressing oligopeptide permease operons (appABCDF and oppABCDF), thereby preventing uptake of oligopeptides required for initiation of sporulation. Acts with SinR as a corepressor of epr expression.<ref>PMID:1906467</ref> <ref>PMID:10383984</ref> <ref>PMID:16923912</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fx/2fxa_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fxa ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Bacillus subtilis]]
[[Category: Bacillus subtilis]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Cuff, M.E.]]
[[Category: Cuff ME]]
[[Category: Edwards, A.]]
[[Category: Edwards A]]
[[Category: Joachimiak, A.]]
[[Category: Joachimiak A]]
[[Category: MCSG, Midwest.Center.for.Structural.Genomics.]]
[[Category: Savchenko A]]
[[Category: Savchenko, A.]]
[[Category: Skarina T]]
[[Category: Skarina, T.]]
[[Category: 1PE]]
[[Category: EDO]]
[[Category: P6G]]
[[Category: PGE]]
[[Category: bacillus subtilis]]
[[Category: hpr]]
[[Category: mcsg]]
[[Category: midwest center for structural genomics]]
[[Category: protease porduction]]
[[Category: protein structure initiative]]
[[Category: psi]]
[[Category: regulation]]
[[Category: structural genomics]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 10:49:24 2007''
Retrieved from "https://proteopedia.org/2fxa"