2res: Difference between revisions

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{{Seed}}
[[Image:2res.png|left|200px]]


<!--
==Tetracenomycin ARO/CYC mutant R69A==
The line below this paragraph, containing "STRUCTURE_2res", creates the "Structure Box" on the page.
<StructureSection load='2res' size='340' side='right'caption='[[2res]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2res]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_glaucescens Streptomyces glaucescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RES OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RES FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2res FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2res OCA], [https://pdbe.org/2res PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2res RCSB], [https://www.ebi.ac.uk/pdbsum/2res PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2res ProSAT]</span></td></tr>
{{STRUCTURE_2res|  PDB=2res  |  SCENE=  }}
</table>
 
== Function ==
===Tetracenomycin ARO/CYC mutant R69A===
[https://www.uniprot.org/uniprot/TCMN_STRGA TCMN_STRGA] The N-terminal domain enhances the formation of an early, partially cyclized intermediate, while the C-terminal domain catalyzes the 3-O-methylation of one or more later intermediates in the biosynthetic pathway. Catalyzes the methylation of tetracenomycin D3 (Tcm D3) to yield Tcm B3. Catalyzes as well the following side reactions: methylation of 8-O-methyl-Tcm D3 to yield Tcm E; and of 9-carboxymethyl-Tcm B3 to yield Tcm A2.
 
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
<!--
Check<jmol>
The line below this paragraph, {{ABSTRACT_PUBMED_18388203}}, adds the Publication Abstract to the page
  <jmolCheckbox>
(as it appears on PubMed at http://www.pubmed.gov), where 18388203 is the PubMed ID number.
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/re/2res_consurf.spt"</scriptWhenChecked>
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    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
{{ABSTRACT_PUBMED_18388203}}
    <text>to colour the structure by Evolutionary Conservation</text>
 
  </jmolCheckbox>
==About this Structure==
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2res ConSurf].
2RES is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Streptomyces_glaucescens Streptomyces glaucescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RES OCA].  
<div style="clear:both"></div>
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:18388203</ref><references group="xtra"/>
[[Category: Large Structures]]
[[Category: Streptomyces glaucescens]]
[[Category: Streptomyces glaucescens]]
[[Category: Ames, B D.]]
[[Category: Ames BD]]
[[Category: Tsai, S C.]]
[[Category: Tsai SC]]
[[Category: Antibiotic biosynthesis]]
[[Category: Aromatase]]
[[Category: Biosynthetic protein]]
[[Category: Cyclase]]
[[Category: Dehydratase]]
[[Category: Helix-grip]]
[[Category: Lyase]]
[[Category: Methyltransferase]]
[[Category: Multifunctional enzyme]]
[[Category: Polyketide]]
[[Category: Tetracenomycin]]
[[Category: Transferase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 21:46:37 2009''
Retrieved from "https://proteopedia.org/2res"